Figure 11
From: Computer simulation analysis of normal and abnormal development of the mammalian diaphragm
Simulation I – homogeneous growth. A representative simulation of the homogeneous growth pattern (see text). Tissue time runs from E11.5 to E13 (36 hours). Cell cycle time linearly increases from 6.5 h to 7.5 h over the course of the simulation. Images are taken at 12 hour intervals (E11.5, E12, E12.5, and E13). Cell color-coding is by PPF of origin (top row) or cell cycle phase (bottom row). Cell color coding conventions are as described in Fig. 8. Note the lack of cells in the anterior central position which corresponds to the non-muscular central tendon. Note also that the model hemi-diaphragms fail to adopt their characteristic curvilinear shape and the posterior PPF defect fails to enlarge significantly.