Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift

Table 4 Steady-state-metabolite levels

			FOLD CHANGE (normalized against 9.5 hr)
Abbreviation	Symbol	Value (mol%)	0 hr	9.5 hr	11.5 hr	13.5 hr	15.5 hr	18.5 hr	20.5 hr
KDHS	X ₁	0.005	1	1	0.79	1.01	1.28	0.80	1.57
DHS	X ₂	0.01	1.09	1	0.58	0.56	0.65	5.08	11.00
Dihydro-C	X ₃	0.036	1.67	1	0.75	2.07	1.20	0.72	4.06
DHS-P	X ₄	0.001	1.23	1	0.41	0.35	0.42	5.98	22.10
PHS	X ₅	0.05	0.84	1	0.51	0.33	0.53	6.76	5.94
PHS-P	X ₆	0.005	0.93	1	0.31	0.16	0.29	10.67	16.86
Phyto-C	X ₇	0.052	0.87	1	0.50	0.51	0.54	0.24	0.94
IPC-g	X ₈	0.102	2.03	1	0.05	0.58	0.76	0.002	3.41
CDP-DAG	X ₉	5.4	1.19	1	0.45	0.70	0.97	0.77	3.18
PS	X ₁₀	8.4	0.78	1	1.26	2.73	3.45	4.08	8.25
PA	X ₁₁	3	1.08	1	0.82	1.48	2.14	2.46	5.16
Pal-CoA	X ₁₂	0.01 ^(*)	0.99	1	0.96	1.17	1.14	0.94	1.30
Serine	X ₁₃	2600 ^(*)	1	1	1	1	1	1	1
DAG	X ₁₄	0.1	1.27	1	0.97	1.20	1.78	1.68	3.86
PI	X ₁₅	16.7	1.05	1	0.58	0.76	1.16	0.36	1.77
Inositol	X ₁₆	24.1 ^(*)	1	1	1	1	1	1	1
CDP-Eth	X ₁₇	22	0.48	1	0.04	0.02	0.03	12.72	24.37
MIPC-g	X ₁₈	0.14	1.58	1	0.36	1.23	1.09	0.05	1.83
M(IP)2C-g	X ₁₉	0.0085	1.53	1	0.25	0.74	1.44	0.04	3.26
IPC-m	X ₂₀	0.918	2.03	1	0.05	0.58	0.76	0.002	3.41
MIPC-m	X ₂₁	1.26	1.58	1	0.36	1.23	1.09	0.05	1.83
M(IP)2C-m	X ₂₂	0.0765	1.53	1	0.25	0.74	1.44	0.04	3.26
C26-CoA	X ₂₃	0.5	0.87	1	3.60	3.62	2.57	0.07	0.03
Mal-CoA	X ₂₄	183 ^(*)	1.03	1	0.35	0.47	0.31	0.84	10.52
Ac-CoA	X ₂₅	870 ^(*)	1	1	1	1	1	1	1
Total IPC	X₈ + X₂₀	1.02	2.03	1	0.05	0.58	0.76	0.002	3.41
Total MIPC	X₁₈ + X₂₁	1.4	1.58	1	0.36	1.23	1.09	0.05	1.83
Total MIP₂C	X₁₉ + X₂₂	0.085	1.53	1	0.25	0.74	1.44	0.04	3.26
Total_Ceramide	X₃ + X₇	0.088	1.20	1	0.60	1.15	0.81	0.44	2.21

(*) μM. Steady-state metabolite levels corresponding to published microarray results from the diauxic shift time course of Gash and Spellman [2]. Each case is represented as fold change of the value presented in Alvarez-Vasquez et al. [9]. "Zero" corresponds to quiescence.

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