Figure 11

Model-predicted dynamic responses of parameters in pancreatic β -cells for independent [Ca²⁺] _c oscillations at 9 mM glucose concentration. A: independent [Ca²⁺]_c oscillations (Appendix) and simulated [Ca²⁺]_m transient in response to [Ca²⁺]_c oscillations; B: Ψ_m, [ADP]_c and [NADH]_m; C: glucose consumption (J_glu, Equation 1) and oxygen consumption (J_O2, Equation 6). All other parameters set points were taken for basal conditions (Tables 2 and 3). Variations in the oxidative phosphorylation rate (as J_ph) were determined in our model mainly by the [ADP]_c changes (Equation 7) and this rate increased with [ADP]_c increase following [Ca²⁺]_c rise, that in turn decreased Ψ_m and increased O₂ consumption rate.