Figure 4
From: Glucose sensing in the pancreatic beta cell: a computational systems analysis
Effect of increasing glucose at different leak activity. A. [Ca2+]c; B. Ψm. To simulate the increase leak activity we magnified the proton leak rate twofold by increasing Plr (Plr = 0.0036 μ M ms-1) in Equation 8. As expected, one effect was to reduce the inner membrane potential, and thus the ATP/ADP ratio. To simulate the decreased leak activity we diminished the proton leak rate twofold by decreasing Pir in Equation 8 (Pir = 0.0 μ M ms"1) (see text for explanation). All other parameters were set as in Tables 2 and 3.