From: Glucose sensing in the pancreatic beta cell: a computational systems analysis
Model parameters: | Value | Units | Eq. | References |
---|---|---|---|---|
Vmglu | 0.011 | μ M ms-1 | 1 | |
KmATP | 500 | μ M | 1 | [26] |
Kmgl | 7 | mM | 1 | [26] |
hgl | 1.7 | Ul | 1 | [26] |
VmGPD | 0.5 | μ M ms-1 | 2 | Ad |
KmG3P | 200 | μ M | 2 | [138] |
KgNc | 0.09 | Ul | 2 | [139] |
VmLD | 1.2 | μ M ms-1 | 3 | Ad |
KmLD | 47.5 | μ M | 3 | [139] |
kLNc | 1 | Ul | 3 | [139] |
VmPDH | 0.3 | μ M ms-1 | 4 | [138] |
Kmpyr | 47.5 | pM | 4A | [139] |
KPNm | 81 | Ul | 4B | [139] |
U1 | 1.5 | Ul | 4C | [29] |
U2 | 1.1 | Ul | 4C | [29] |
KCam | 0.05 | μ M | 4C | [29] |
vme | 22 | μ M ms-1 | 5 | Ad |
KmNH | 3000 | μ M | 5A | [123] |
kAT | -0.00492 | mV-1 | 5C | Fit to [24] |
kBT | -0.00443 | mV-1 | 5C | Fit to [24] |
Vmph | 8 | μ M ms-1 | 7 | Ad |
KmADP | 20 | μ M | 7A | [26] |
hph | 2 | Ul | 7A | [26] |
hp | 8 | Ul | 7B | Ad |
KPh | 131.4 | mV | 7B | Ad |
KPCam | 0.165 | μ M | 7C | [130] |
Plb | 0.0012 | μ M ms-1 | 8 | Ad |
Plr | 0.0012 | μ M ms-1 | 8 | Ad |
klp | 0.0305 | mV-1 | 8 | Fit to [24] |
TNADH | 0.05 | μ M ms-1 | 9 | Ad |
KTNm | 16.78 | Ul | 9 | [76] |
KTNc | 0.002 | Ul | 9 | Ad |
PCa | 0.004 | ms-1 | 10 | Ad |
am | 0.2 | Ul | 10 | [130] |
ai | 0.341 | Ul | 10 | [130] |
VmNC | 0.025 | μ M ms-1 | 11 | Ad |
KNaj | 8000 | μ M | 11 | [130] |
KCaj | 8 | μ M | 11 | [130] |
kgpd | 0.00001 | ms-1 | 12 | Ad |
kNADHm | 0.0001 | ms-1 | 14 | Ad |
kNADPc | 0.0001 | ms-1 | 16 | Ad |
k ATP | 0.00004 | ms-1 | 20 | Ad |
k ATP,Ca | 0.00009 | μ M-1ms-1 | 20 | Ad |
[Ca2+]R | 0.09 | μ M | 23 | Ad |
kACa | 0.25 | μ M | 23 | Ad |
KAD | 25 | Ul | 23 | Ad |
hCa | 4 | Ul | 23 | Ad |