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Table 3 Standard parameter values (see text for explanations)

From: Glucose sensing in the pancreatic beta cell: a computational systems analysis

Model parameters:

Value

Units

Eq.

References

Vmglu

0.011

μ M ms-1

1

Rescaled from Refs. [29, 137]

KmATP

500

μ M

1

[26]

Kmgl

7

mM

1

[26]

hgl

1.7

Ul

1

[26]

VmGPD

0.5

μ M ms-1

2

Ad

KmG3P

200

μ M

2

[138]

KgNc

0.09

Ul

2

[139]

VmLD

1.2

μ M ms-1

3

Ad

KmLD

47.5

μ M

3

[139]

kLNc

1

Ul

3

[139]

VmPDH

0.3

μ M ms-1

4

[138]

Kmpyr

47.5

pM

4A

[139]

KPNm

81

Ul

4B

[139]

U1

1.5

Ul

4C

[29]

U2

1.1

Ul

4C

[29]

KCam

0.05

μ M

4C

[29]

vme

22

μ M ms-1

5

Ad

KmNH

3000

μ M

5A

[123]

kAT

-0.00492

mV-1

5C

Fit to [24]

kBT

-0.00443

mV-1

5C

Fit to [24]

Vmph

8

μ M ms-1

7

Ad

KmADP

20

μ M

7A

[26]

hph

2

Ul

7A

[26]

hp

8

Ul

7B

Ad

KPh

131.4

mV

7B

Ad

KPCam

0.165

μ M

7C

[130]

Plb

0.0012

μ M ms-1

8

Ad

Plr

0.0012

μ M ms-1

8

Ad

klp

0.0305

mV-1

8

Fit to [24]

TNADH

0.05

μ M ms-1

9

Ad

KTNm

16.78

Ul

9

[76]

KTNc

0.002

Ul

9

Ad

PCa

0.004

ms-1

10

Ad

am

0.2

Ul

10

[130]

ai

0.341

Ul

10

[130]

VmNC

0.025

μ M ms-1

11

Ad

KNaj

8000

μ M

11

[130]

KCaj

8

μ M

11

[130]

kgpd

0.00001

ms-1

12

Ad

kNADHm

0.0001

ms-1

14

Ad

kNADPc

0.0001

ms-1

16

Ad

k ATP

0.00004

ms-1

20

Ad

k ATP,Ca

0.00009

μ M-1ms-1

20

Ad

[Ca2+]R

0.09

μ M

23

Ad

kACa

0.25

μ M

23

Ad

KAD

25

Ul

23

Ad

hCa

4

Ul

23

Ad

  1. Ad -Adjusted to fit glucose consumption rate and others conditions (see text).