A biochemical hypothesis on the formation of fingerprints using a turing patterns approach
© Garzón-Alvarado and Ramírez Martinez; licensee BioMed Central Ltd. 2011
Received: 26 May 2011
Accepted: 28 June 2011
Published: 28 June 2011
Fingerprints represent a particular characteristic for each individual. Characteristic patterns are also formed on the palms of the hands and soles of the feet. Their origin and development is still unknown but it is believed to have a strong genetic component, although it is not the only thing determining its formation. Each fingerprint is a papillary drawing composed by papillae and rete ridges (crests). This paper proposes a phenomenological model describing fingerprint pattern formation using reaction diffusion equations with Turing space parameters.
Several numerical examples were solved regarding simplified finger geometries to study pattern formation. The finite element method was used for numerical solution, in conjunction with the Newton-Raphson method to approximate nonlinear partial differential equations.
The numerical examples showed that the model could represent the formation of different types of fingerprint characteristics in each individual.
Fingerprints represent a particular characteristic for each individual [1–10]. These enable individuals to be identified through the embossed patterns formed on fingertips. Characteristic patterns are also formed on the palms of the hands and soles of the feet . Their origin and development is still unknown but it is believed to have a strong genetic component, although it is not the only thing determining its formation. Each fingerprint is a papillary drawing composed by papillae and rete ridges (crests) [1–6]. These crests are epidermal ridges having unique characteristics .
Alternately to the proposal made by Kucken , this paper presents a hypothesis about fingerprint formation from a biochemical effect. The proposed model uses a reaction-diffusion-convection (RDC) system. Following a similar approach to that used in [11, 12], a glycolysis reaction model has been used to simulate the appearance of patterns on fingertips. A solution method on three dimensional surfaces using total Lagrangian formulation is provided for resolving the reaction diffusion (RD) equations. Equations whose parameters are in the Turing space have been used for pattern formation; therefore, the patterns found are Turing patterns which are stable in time and unstable in space. Such stability is similar to that found in fingerprint formation. The model explained in  was used for fold growth where the formation of the folds depends on the concentration of a biochemical substance present on the surface of the skin.
Reaction-diffusion (RD) system
where u 1 and u 2 were the concentrations of chemical species present in reaction terms f and g, d was the dimensionless diffusion coefficient and γ was a constant in a dimensionless system .
where f1 and g1 indicated the derivatives of the reaction regarding concentration variables, for example . These restrictions were evaluated at the point of equilibrium by f(u1, u2) = g(u1, u2) = 0.
Equations (1) and constraints (2) led to developing the dynamic system branch of research [11, 18]: Turing instability. Turing pattern theory has helped explain the formation of complex biological patterns such as the spots found on the skin of some animals [15, 16] and morphogenesis problems . It has also been experimentally proven that the behavior of some RD systems produce traveling wave and stable spatial patterns [21–23].
where δ and κ were the model's dimensionless parameters. The steady state points were given by . Applying constraints (2) to model (3) in steady state point (u1, u2)0 a set of constraints was obtained. This constraint establishes the geometric site known as Turing space .
where K was a constant determining growth rate.
The finite element method  was used to solve the RDC system described above in (5) and the Newton-Raphson method  to solve the non-linear system of partial differential equations arising from the formulation. The seed coat surface pattern growth field was imposed by solving equation (4), giving the new configuration (current) and velocity field to be included in the RD problem.
The solution of the RD equations by using the finite element method is shown below.
Solution for RDC system
where it should be noted that
where U1 and U2 were the concentrations of each species in initial configuration Ω0, i.e. U(X,t) = u( X ( X ,t),t). Besides was the inverse of the strained gradient given by , x i were the current coordinates (at each instant of time) and X I were the initial coordinates (of reference, where the calculations were to be made) [29, 30].
where U was either of the two studied species (U1 or U2), W was the weighting, J was the Jacobian (and equaled the determinant for strained gradient F) and C -1 was the inverse of the Cauchy-Green tensor on the right [27, 28].
where J was strained gradient determinant, C -1 was the inverse of the Cauchy-Green tensor on the right p, s = 1, ..., nnod and I, J = 1, .., dim, where dim was the dimension in which the problem was resolved. Therefore, using equations (11) and (12), the Newton-Raphson method could be implemented to solve the RD system using its material description. It should be noted that (11) and (12) were integrated in the initial configuration .
Applying the velocity fields
where the velocity term had direction and magnitude depending on the material point of surface S.
Aspects of computational implementation
The formulation described above was used for implementing the RD model using the finite element method. It should be noted that although the surface was orientated in a 3D space, the numerical calculations were done in 2D. The normal for each element (Z') was thus found and the prime axes (X'Y') forming a parallel plane to the element plane were located. The geometry was enmeshed by using first order triangular elements with three nodes. Therefore, the calculation was simplified from a 3D system to a system which solved two-dimensional RD models at every instant of time. The relationship between the X'Y'Z 'and XYZ axes could be obtained by a transformation matrix T .
A program in FORTRAN was used for solving the system of equations resulting from the finite element method with the Newton-Raphson method and the following examples were solved on a Laptop having 4096 MB of RAM and 800 MHz processor speed. In all cases, the dimensionless problem was solved with random conditions around the steady state [12, 24] for the RD system.
Figure 4b)-4c) shows surface pattern evolution. The formation of labyrinths and blind spots in the grooves approximating the shape of the fingerprint patterns can be observed (Figure 4a). The pattern obtained was given by bands of high concentration of a chemical species, for which the domain had grown in the normal direction to the surface and hence generated its own fingerprint grooves.
Discussion and conclusions
This paper has presented a phenomenological model based on RD equations to predict the formation of rough patterns on the tips of the fingers, known as fingerprints. The application of the RD models with Turing space parameters is an area of constant work and controversy in biology [31, 32] and has attracted recent interest due to the work of Sick et al.,  confirming the validity of RD equations in a model of the appearance of the hair follicle. From this point of view, the work developed in this article has illustrated RD equation validity for representing complex biological patterns, such as patterns formed in fingerprints.
This paper proposes the existence of a reactive system (activator-inhibitor) on the skin surface giving an explanation for the patterns found. The high stability of the emergence of the patterns can also be explained, i.e. the repetition of the patterns was due to a specialized biochemical system allowing the formation of wrinkles in the fingerprints and skin pigmentation.
The formulation of a system of RD equations acting under domain strain was programmed to test this hypothesis. Continuum mechanics thus led to the general form of the RD equations in two- and three-dimensions on domains presenting strain. The resulting equations were similar to those shown in , where major simplifications were carried out on field dilatation. The RD system was solved by the finite element method, using a Newton-Raphson approach to solve the nonlinear problem. This allowed longer time steps and obtaining solutions closer to reality. The results showed that RD equations have continuously changing patterns.
Additionally, it should be noted that the results obtained with the RD mathematical model was based on assumptions and simplifications that should be discussed for future models.
The model was based on the assumption of a tightly coupled biochemical system (non-linear) between an activator and an inhibitor generating Turing patterns. As far as the authors know, this assumption has not been tested experimentally, so the model is a hypothesis to be tested in future research. It is also feasible, as in other biological models (see ), that there were a large number of chemical factors (morphogens) involved, interacting to form superficial patterns found in the fingers. In the case of patterns with superficial roughness, the biochemical system could also interact with its own mechanical growth factors. Therefore, determining the exact influence of each biochemical and mechanical factor on the formation of surface patterns becomes an experimental challenge that will reveal the morphogenesis of fingerprints.
This work was financially supported by Division de Investigación de Bogotá, of Universidad Nacional de Colombia, under title Modelling in Mechanical and Biomedical Engineering, Phase II.
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