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Table 1 Parameter values for HGI subjects Order: originator/test

From: Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products

  

Subject

       

Parameter 1

Default

1

3

4

5

7

8

9

10

XScale

1

0.5

0.5/1.0

0.25/0.5

.125

.25/.5

.5

.125/.5

.125

YScale

120

330

220/120

120/330

220/110

110/330

110

110

110

DtoGDelay

1

1

1

1

1

1

1

1

1

DtoGFract

.1

0.1/0.2

.13/.33

.05/0.2

.03/.05

.05/.16

.13/.28

.05/.25

.025/.05

DtoGProb

.8

0.8

0.8

0.8

0.8

.8/.85

.8

.4/.9

.8

DiffGRatio

1

0.8/1

.65/.93

.94/.9

.75/.65

.6/1

.6/.4

.9

.88/.9

GtoPDelay

0

5/4

0

4/0

7/21

4/6

0/3

12/6

0/8

GtoPFract

.1

1.0/0.3

.78/.88

.065/.14

.25/.1

.34/.46

.65/.4

.2/.38

.12/.1

GtoPProb

.8

1.0/0.8

.78/.88

0.89

0.27/.3

.34/.46

.65/.4

.2/.38

.12/.1

G2toPDelay

20

32/20

18/15

19/23

96/86

39

20/21

97/26

0/58

G2toPFract

.1

0.3/0.1

0.2/0.5

1.0/0.3

0.12

.13

.23/.24

.11/.23

.05/.23

G2toPProb

.8

0.3/0.8

0.2/0.5

1.0/0.3

.13/.12

.13

.23/.24

.11/.23

.05/.23

PtoEDelay

0

7/0

10/3

14/7

36/0

18/11

1/11

20/0

35/48

PtoEFract

0.1

.25/.11

.14/.26

.69/.9

.125/.24

.15/.1

.14/.12

.22/.48

.11

PtoEProb

0.8

.6/.88

.8/.93

.3/.86

0.5/.4

1/.8

1/.9

.5/.4

.8

  1. 1 Additional parameter information is provided in Additional file 2.