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  1. Computational identification of transcription factor binding sites (TFBSs) is a rapid, cost-efficient way to locate unknown regulatory elements. With increased potential for high-throughput genome sequencing, ...

    Authors: Mingfeng Tan, Dong Yu, Yuan Jin, Lei Dou, Beiping LI, Yuelan Wang, Junjie Yue and Long Liang

    Citation: Theoretical Biology and Medical Modelling 2012 9:19

    Content type: Research

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  2. Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft), immunosuppression therapies are used, which have cons...

    Authors: AndreaDe Gaetano, Alice Matone, Annamaria Agnes, Pasquale Palumbo, Francesco Ria and Sabina Magalini

    Citation: Theoretical Biology and Medical Modelling 2012 9:18

    Content type: Research

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  3. Several formulations have been proposed in order to model human growth from birth to maturity. They are usually based on “ad hoc” heuristic assumptions. In the present contribution we adopt, as an alternative,...

    Authors: Antonio S Gliozzi, Caterina Guiot, Pier Paolo Delsanto and Dan A Iordache

    Citation: Theoretical Biology and Medical Modelling 2012 9:17

    Content type: Research

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  4. Consensus exists that several bariatric surgery procedures produce a rapid improvement of glucose homeostasis in obese diabetic patients, improvement apparently uncorrelated with the degree of eventual weight ...

    Authors: Puntip Toghaw, Alice Matone, Yongwimon Lenbury and Andrea De GAETANO

    Citation: Theoretical Biology and Medical Modelling 2012 9:16

    Content type: Research

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  5. An allometric relationship between different electrocardiogram (ECG) parameters and infarcted ventricular mass was assessed in a myocardial infarction (MI) model in New Zealand rabbits.

    Authors: Maria P Bonomini, Pedro D Arini, Germán E Gonzalez, Bruno Buchholz and Max E Valentinuzzi

    Citation: Theoretical Biology and Medical Modelling 2012 9:15

    Content type: Research

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  6. This article proposes a model of bone remodeling that encompasses mechanical and electrical stimuli. The remodeling formulation proposed by Weinans and collaborators was used as the basis of this research, wit...

    Authors: Diego A Garzón-Alvarado, Angélica M Ramírez-Martínez and Carmen Alicia Cardozo de Martínez

    Citation: Theoretical Biology and Medical Modelling 2012 9:14

    Content type: Research

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  7. Lordosis is the bending of the lumbar spine that gives the vertebral column of humans its characteristic ventrally convex curvature. Infants develop lordosis around the time when they acquire bipedal locomotio...

    Authors: Heiko Wagner, Anne Liebetrau, David Schinowski, Thomas Wulf and Marc HE de Lussanet

    Citation: Theoretical Biology and Medical Modelling 2012 9:13

    Content type: Research

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  8. An accepted hypothesis states that coronary atherosclerosis (CA) is initiated by endothelial dysfunction due to inflammation and high levels of LDL-C, followed by deposition of lipids and macrophages from the ...

    Authors: Vladimir M Subbotin

    Citation: Theoretical Biology and Medical Modelling 2012 9:11

    Content type: Research

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  9. Recent studies have implicated viral characteristics in accounting for the variation in the HIV set-point viral load (spVL) observed among individuals. These studies have suggested that the spVL might be a her...

    Authors: Diego F Cuadros and Gisela García-Ramos

    Citation: Theoretical Biology and Medical Modelling 2012 9:9

    Content type: Research

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  10. The fields of molecular biology and computer science have cooperated over recent years to create a synergy between the cybernetic and biosemiotic relationship found in cellular genomics to that of information ...

    Authors: David J D'Onofrio, David L Abel and Donald E Johnson

    Citation: Theoretical Biology and Medical Modelling 2012 9:8

    Content type: Review

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  11. In clinical practice, the common strategy for immunotherapy of nasopharyngeal carcinoma (NPC) is to infuse cytotoxic T-lymphocyte (CTL) lines several times by intravenous injection, but it is difficult by labo...

    Authors: Wang Shengjun, Guo Yunbo, Song Liyan, Li Jinming and Deng Qinkai

    Citation: Theoretical Biology and Medical Modelling 2012 9:6

    Content type: Research

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  12. The study of typical morphological variations using quantitative, morphometric descriptors has always interested biologists in general. However, unusual examples of form, such as abnormalities are often encoun...

    Authors: Peter Claes, Katleen Daniels, Mark Walters, John Clement, Dirk Vandermeulen and Paul Suetens

    Citation: Theoretical Biology and Medical Modelling 2012 9:5

    Content type: Research

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  13. In this paper, a new mathematical model is developed to represent the interaction between healthy and cancer cells in the human body, focusing on the role of environmental factors and quality of life in the pr...

    Authors: Ali Ghaffari and Mostafa Khazaee

    Citation: Theoretical Biology and Medical Modelling 2012 9:4

    Content type: Research

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  14. The aim of this study is to assess the protective effects of Ginkgo biloba's (GB) extract against chemotherapeutic-induced reproductive toxicity using a data mining tool, namely Neural Network Clustering (NNC) on...

    Authors: Amr Amin, Doaa Mahmoud-Ghoneim, Muhammed I Syam and Sayel Daoud

    Citation: Theoretical Biology and Medical Modelling 2012 9:1

    Content type: Research

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  15. Solid tumors are heterogeneous in composition. Cancer stem cells (CSCs) are believed to drive tumor progression, but the relative frequencies of CSCs versus non-stem cancer cells span wide ranges even within t...

    Authors: Charles I Morton, Lynn Hlatky, Philip Hahnfeldt and Heiko Enderling

    Citation: Theoretical Biology and Medical Modelling 2011 8:48

    Content type: Research

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  16. With the development of experimental techniques and bioinformatics, the quantity of data available from protein-protein interactions (PPIs) is increasing exponentially. Functional modules can be identified fro...

    Authors: Xia Wang, Junjie Yue, Xianwen Ren, Yuelan Wang, Mingfeng Tan, Beiping LI and Long Liang

    Citation: Theoretical Biology and Medical Modelling 2011 8:47

    Content type: Research

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  17. Multiscale agent-based modeling (MABM) has been widely used to simulate Glioblastoma Multiforme (GBM) and its progression. At the intracellular level, the MABM approach employs a system of ordinary differential e...

    Authors: Le Zhang, Beini Jiang, Yukun Wu, Costas Strouthos, Phillip Zhe Sun, Jing Su and Xiaobo Zhou

    Citation: Theoretical Biology and Medical Modelling 2011 8:46

    Content type: Research

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  18. Elucidating the effects of drugs on solid tumours is a highly challenging multi-level problem, since this involves many complexities associated with transport and cellular response, which in turn is characteri...

    Authors: Cong Liu, J Krishnan and Xiao Yun Xu

    Citation: Theoretical Biology and Medical Modelling 2011 8:45

    Content type: Research

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  19. Epidemiological studies have shown that imposing travel restrictions to prevent or delay an influenza pandemic may not be feasible. To delay an epidemic substantially, an extremely high proportion of trips (~9...

    Authors: Elson HY Lam, Benjamin J Cowling, Alex R Cook, Jessica YT Wong, Max SY Lau and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2011 8:44

    Content type: Research

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  20. Competing risks, which are particularly encountered in medical studies, are an important topic of concern, and appropriate analyses must be used for these data. One feature of competing risks is the cumulative...

    Authors: Zahra Shayan, SeyyedMohammadTaghi Ayatollahi and Najaf Zare

    Citation: Theoretical Biology and Medical Modelling 2011 8:43

    Content type: Research

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  21. Expanded polytetrafluoroethylene (ePTFE) vascular grafts frequently develop occlusive neointimal hyperplasia as a result of myofibroblast over-growth, leading to graft failure. ePTFE exhibits higher ultrasound...

    Authors: Mark R Brinton, Russell J Stewart, Alfred K Cheung, Douglas A Christensen and Yan-Ting E Shiu

    Citation: Theoretical Biology and Medical Modelling 2011 8:42

    Content type: Research

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  22. Even though many functions of protein-x from the Hepatitis B virus (HBV) have been revealed, the nature of protein-x is yet unknown. This protein is well-known for its transactivation activity through interact...

    Authors: Ashraf Mohamadkhani, Parisa Shahnazari, Zarrin Minuchehr, Armin Madadkar-Sobhani, Mahmoud Jeddi Tehrani, Ferdous Rastgar Jazii and Hossein Poustchi

    Citation: Theoretical Biology and Medical Modelling 2011 8:41

    Content type: Research

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  23. Thousands of children experience cardiac arrest events every year in pediatric intensive care units. Most of these children die. Cardiac arrest prediction tools are used as part of medical emergency team evalu...

    Authors: Curtis E Kennedy and James P Turley

    Citation: Theoretical Biology and Medical Modelling 2011 8:40

    Content type: Research

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  24. The concept of disaster surge has arisen in recent years to describe the phenomenon of severely increased demands on healthcare systems resulting from catastrophic mass casualty events (MCEs) such as natural d...

    Authors: Erik R Barthel, James R Pierce, Catherine J Goodhue, Henri R Ford, Tracy C Grikscheit and Jeffrey S Upperman

    Citation: Theoretical Biology and Medical Modelling 2011 8:38

    Content type: Research

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  25. Increasing the predictability and reducing the rate of side effects of oral anticoagulant treatment (OAT) requires further clarification of the cause of about 50% of the interindividual variability of OAT resp...

    Authors: Alexandru D Corlan and John Ross

    Citation: Theoretical Biology and Medical Modelling 2011 8:37

    Content type: Research

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  26. We review grounding issues that influence the scientific usefulness of any biomedical multiscale model (MSM). Groundings are the collection of units, dimensions, and/or objects to which a variable or model con...

    Authors: C Anthony Hunt, Glen EP Ropella, Tai ning Lam and Andrew D Gewitz

    Citation: Theoretical Biology and Medical Modelling 2011 8:35

    Content type: Review

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  27. In nature, bacteria often exist as biofilms. Biofilms are communities of microorganisms attached to a surface. It is clear that biofilm-grown cells harbor properties remarkably distinct from planktonic cells. ...

    Authors: Andrew A Shalá, Silvia Restrepo and Andrés F González Barrios

    Citation: Theoretical Biology and Medical Modelling 2011 8:34

    Content type: Research

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  28. There is a growing realization that alterations in host-pathogen interactions (HPI) can generate disease phenotypes without pathogen invasion. The gut represents a prime region where such HPI can arise and man...

    Authors: John B Seal, John C Alverdy, Olga Zaborina and Gary An

    Citation: Theoretical Biology and Medical Modelling 2011 8:33

    Content type: Research

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  29. It was recently shown that the treatment effect of an antibody can be described by a consolidated parameter which includes the reaction rates of the receptor-toxin-antibody kinetics and the relative concentrat...

    Authors: Vladas Skakauskas, Pranas Katauskis and Alex Skvortsov

    Citation: Theoretical Biology and Medical Modelling 2011 8:32

    Content type: Research

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  30. Arsenic in drinking water, a major health hazard to millions of people in South and East Asia and in other parts of the world, is ingested primarily as trivalent inorganic arsenic (iAs), which then undergoes h...

    Authors: Sean D Lawley, Molly Cinderella, Megan N Hall, Mary V Gamble, H Frederik Nijhout and Michael C Reed

    Citation: Theoretical Biology and Medical Modelling 2011 8:31

    Content type: Research

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  31. This paper discusses the properties of cancer cells from a new perspective based on an analogy with phase transitions in physical systems. Similarities in terms of instabilities and attractor states are outlin...

    Authors: Paul CW Davies, Lloyd Demetrius and Jack A Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2011 8:30

    Content type: Research

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  32. Upon the addition of protons to an aqueous solution, a component of the H+ load will be bound i.e. buffered. In an aqueous solution containing a triprotic acid, H+ can be bound to three different states of the ac...

    Authors: Minhtri K Nguyen, Liyo Kao and Ira Kurtz

    Citation: Theoretical Biology and Medical Modelling 2011 8:29

    Content type: Research

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  33. Personalised cancer therapy, such as that used for bronchial carcinoma (BC), requires treatment to be adjusted to the patient's status. Individual risk for progression is estimated from clinical and molecular-...

    Authors: Wolfgang Kössler, Anette Fiebeler, Arnulf Willms, Tina ElAidi, Bernd Klosterhalfen and Uwe Klinge

    Citation: Theoretical Biology and Medical Modelling 2011 8:28

    Content type: Research

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  34. Most information on the dose-response of radiation-induced cancer is derived from data on the A-bomb survivors. Since, for radiation protection purposes, the dose span of main interest is between zero and one ...

    Authors: Uwe Schneider, Marcin Sumila and Judith Robotka

    Citation: Theoretical Biology and Medical Modelling 2011 8:27

    Content type: Research

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  35. Texture analysis (TA) of histological images has recently received attention as an automated method of characterizing liver fibrosis. The colored staining methods used to identify different tissue components r...

    Authors: Doaa Mahmoud-Ghoneim

    Citation: Theoretical Biology and Medical Modelling 2011 8:25

    Content type: Research

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  36. Fingerprints represent a particular characteristic for each individual. Characteristic patterns are also formed on the palms of the hands and soles of the feet. Their origin and development is still unknown bu...

    Authors: Diego A Garzón-Alvarado and Angelica M Ramírez Martinez

    Citation: Theoretical Biology and Medical Modelling 2011 8:24

    Content type: Research

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  37. Herpes simplex type II (HSV-2) is a member of the family herpesviridae. Human infection with this double stranded linear DNA virus causes genital ulcerative disease and existing treatment options only serve to re...

    Authors: Misaki Wayengera

    Citation: Theoretical Biology and Medical Modelling 2011 8:23

    Content type: Research

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  38. In this paper we provide a review of selected mathematical ideas that can help us better understand the boundary between living and non-living systems. We focus on group theory and abstract algebra applied to ...

    Authors: Edward A Rietman, Robert L Karp and Jack A Tuszynski

    Citation: Theoretical Biology and Medical Modelling 2011 8:21

    Content type: Review

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  39. 7D-cadherins like LI-cadherin are cell adhesion molecules and represent exceptional members of the cadherin superfamily. Although LI-cadherin was shown to act as a functional Ca2+-dependent adhesion molecule, lin...

    Authors: Mareike Ahl, Agnes Weth, Sebastian Walcher and Werner Baumgartner

    Citation: Theoretical Biology and Medical Modelling 2011 8:18

    Content type: Research

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