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  1. The COVID-19 pandemic poses a serious threat to global health, and pathogenic mutations are a major challenge to disease control. We developed a statistical framework to explore the association between molecul...

    Authors: Shi Zhao, Jingzhi Lou, Lirong Cao, Hong Zheng, Marc K. C. Chong, Zigui Chen, Benny C. Y. Zee, Paul K. S. Chan and Maggie H. Wang

    Citation: Theoretical Biology and Medical Modelling 2021 18:10

    Content type: Research

    Published on:

  3. The superchiasmatic nucleus (SCN) serves as the primary circadian (24hr) clock in mammals and is known to control important physiological functions such as the sleep-wake cycle, hormonal rhythms, and neurotran...

    Authors: Ruby Kim and Michael C. Reed

    Citation: Theoretical Biology and Medical Modelling 2021 18:8

    Content type: Research

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  4. Influenza is a public health issue that needs to be addressed strategically. The assessment of detailed infectious profiles is an important part of this effort. Household transmission data play a key role in e...

    Authors: Masaya M. Saito, Nobuo Hirotsu, Hiroka Hamada, Mio Takei, Keisuke Honda, Takamichi Baba, Takahiro Hasegawa and Yoshitake Kitanishi

    Citation: Theoretical Biology and Medical Modelling 2021 18:7

    Content type: Research

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  5. The effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in previous researches. In fact, microcir...

    Authors: Fan He, Lu Hua and Tingting Guo

    Citation: Theoretical Biology and Medical Modelling 2021 18:6

    Content type: Research

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  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yusuke Kakizoe, Yoshiki Koizumi, Yukino Ikoma, Hirofumi Ohashi, Takaji Wakita, Shingo Iwami and Koichi Watashi

    Citation: Theoretical Biology and Medical Modelling 2021 18:5

    Content type: Correction

    Published on:

    The original article was published in Theoretical Biology and Medical Modelling 2021 18:4

  7. Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-res...

    Authors: Yusuke Kakizoe, Yoshiki Koizumi, Yukino Ikoma, Hirofumi Ohashi, Takaji Wakita, Shingo Iwami and Koichi Watashi

    Citation: Theoretical Biology and Medical Modelling 2021 18:4

    Content type: Research

    Published on:

    The Correction to this article has been published in Theoretical Biology and Medical Modelling 2021 18:5

  9. The functions of the nasal cavity are very important for maintaining the internal environment of the lungs since the inner walls of the nasal cavity control the temperature and saturation of the inhaled air wi...

    Authors: Alibek Issakhov, Yeldos Zhandaulet, Aizhan Abylkassymova and Assylbek Issakhov

    Citation: Theoretical Biology and Medical Modelling 2021 18:2

    Content type: Research

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  10. Stochastic processes leading voltage-gated ion channel dynamics on the nerve cell membrane are a sufficient condition to describe membrane conductance through statistical mechanics of disordered and complex sy...

    Authors: Gianluigi Zangari del Balzo

    Citation: Theoretical Biology and Medical Modelling 2021 18:1

    Content type: Research

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    The Correction to this article has been published in Theoretical Biology and Medical Modelling 2021 18:9

  11. To employ the benchmark dose (BMD) method in toxicological risk assessment, it is critical to understand how the BMD lower bound for reference dose calculation is selected following statistical fitting procedu...

    Authors: Keita Yoshii, Hiroshi Nishiura, Kaoru Inoue, Takayuki Yamaguchi and Akihiko Hirose

    Citation: Theoretical Biology and Medical Modelling 2020 17:13

    Content type: Research

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  12. Currently, due to the huge progress in the field of information technologies and computer equipment, it is important to use modern approaches of artificial intelligence in order to process extensive chemical i...

    Authors: Galina Samigulina and Zarina Samigulina

    Citation: Theoretical Biology and Medical Modelling 2020 17:12

    Content type: Research

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  13. Seasonal influenza poses a significant public health and economic burden, associated with the outcome of infection and resulting complications. The true burden of the disease is difficult to capture due to the...

    Authors: Zachary McCarthy, Safia Athar, Mahnaz Alavinejad, Christopher Chow, Iain Moyles, Kyeongah Nah, Jude D. Kong, Nishant Agrawal, Ahmed Jaber, Laura Keane, Sam Liu, Myles Nahirniak, Danielle St Jean, Razvan Romanescu, Jessica Stockdale, Bruce T. Seet…

    Citation: Theoretical Biology and Medical Modelling 2020 17:11

    Content type: Research

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  14. HIV infected patients may experience many intermediate events including between-event transition throughout their follow up. Through modelling these transitions, we can gain a deeper understanding of HIV disea...

    Authors: Zelalem G. Dessie, Temesgen Zewotir, Henry Mwambi and Delia North

    Citation: Theoretical Biology and Medical Modelling 2020 17:10

    Content type: Research

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  15. On December 31, 2019, the World Health Organization was alerted to the occurrence of cases of pneumonia in Wuhan, Hubei Province, China, that were caused by an unknown virus, which was later identified as a co...

    Authors: Soyoung Kim, Sunhwa Choi, Youngsuk Ko, Moran Ki and Eunok Jung

    Citation: Theoretical Biology and Medical Modelling 2020 17:9

    Content type: Research

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  16. Genes, proteins, or cells influence each other and consequently create patterns, which can be increasingly better observed by experimental biology and medicine. Thereby, descriptive methods of statistics and b...

    Authors: Marco Albrecht, Philippe Lucarelli, Dagmar Kulms and Thomas Sauter

    Citation: Theoretical Biology and Medical Modelling 2020 17:8

    Content type: Review

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  17. This paper intends to check whether and how a hypothetical dengue vaccine could contribute to issue of evolution of bacteria resistance against antibiotics by reducing the number of patients that would inappro...

    Authors: Ana Kurauchi, Claudio Jose Struchiner, Annelies Wilder-Smith and Eduardo Massad

    Citation: Theoretical Biology and Medical Modelling 2020 17:7

    Content type: Research

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  18. Tuberculosis (TB) is one of the most important health topics in the world. Directly observed treatment and short course chemotherapy (DOTS) strategy combines medicine care and modern health system firmly, and ...

    Authors: Siyu Liu, Yingjie Bi and Yawen Liu

    Citation: Theoretical Biology and Medical Modelling 2020 17:6

    Content type: Research

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  19. Alzheimer’s disease (AD) is a degenerative brain disease. A novel agent-based modelling framework was developed in NetLogo 3D to provide fundamental insights into the potential mechanisms by which a microbe (eg.

    Authors: Shalini Sundar, Carly Battistoni, Ryan McNulty, Fernando Morales, Jonathan Gorky, Henry Foley and Prasad Dhurjati

    Citation: Theoretical Biology and Medical Modelling 2020 17:5

    Content type: Research

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  23. Estimating HIV incidence is crucial for monitoring the epidemiology of this infection, planning screening and intervention campaigns, and evaluating the effectiveness of control measures. However, owing to the...

    Authors: Xiaodan Sun, Hiroshi Nishiura and Yanni Xiao

    Citation: Theoretical Biology and Medical Modelling 2020 17:1

    Content type: Review

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  24. Variations of gene expression levels play an important role in tumors. There are numerous methods to identify differentially expressed genes in high-throughput sequencing. Several algorithms endeavor to identi...

    Authors: Chengyou Liu, Leilei Zhou, Yuhe Wang, Shuchang Tian, Junlin Zhu, Hang Qin, Yong Ding and Hongbing Jiang

    Citation: Theoretical Biology and Medical Modelling 2019 16:20

    Content type: Review

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  25. Glucose tolerance testing is a tool used to estimate glucose effectiveness and insulin sensitivity in diabetic patients. The importance of such tests has prompted the development and utilisation of mathematica...

    Authors: Ross A. Kelly, Molly J. Fitches, Steven D. Webb, S. R. Pop and Stewart J. Chidlow

    Citation: Theoretical Biology and Medical Modelling 2019 16:21

    Content type: Research

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  26. Gravity, especially hypergravity, can affect the morphology of membranes, and further influence most biological processes. Since vesicle structures are relatively simple, the vesicle can be treated as a vital ...

    Authors: Lili Wang, Weiyi Chen, Hongmei Guo and Airong Qian

    Citation: Theoretical Biology and Medical Modelling 2019 16:19

    Content type: Research

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  27. Associations between disease characteristics and payer-relevant outcomes can be difficult to establish for rare and progressive chronic diseases with sparse available data. We developed an exploratory bridging...

    Authors: Gorana Capkun, Jens Schmidt, Shubhro Ghosh, Harsh Sharma, Thomas Obadia, Ana de Vera, Valery Risson and Billy Amzal

    Citation: Theoretical Biology and Medical Modelling 2019 16:17

    Content type: Research

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  28. Autophagy and apoptosis are two important physiological processes that determine cell survival or death in response to different stress signals. The regulatory mechanisms of these two processes share B-cell ly...

    Authors: Bojie Yang, Quansheng Liu and Yuanhong Bi

    Citation: Theoretical Biology and Medical Modelling 2019 16:18

    Content type: Research

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  29. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are two coronaviruses with demonstrated potential to generate significant nosocomial outbreaks. In particular, MERS continue...

    Authors: Fatima Abdirizak, Rayleen Lewis and Gerardo Chowell

    Citation: Theoretical Biology and Medical Modelling 2019 16:16

    Content type: Research

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  30. Group A streptococcus (GAS) is the most frequent cause of bacterial pharyngitis in school-aged children. The postinfection sequel as acute rheumatic fever (ARF) and rheumatic heart disease that cause morbidity...

    Authors: Natsuda Yokchoo, Nichaphat Patanarapeelert and Klot Patanarapeelert

    Citation: Theoretical Biology and Medical Modelling 2019 16:14

    Content type: Research

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  32. Photothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue ...

    Authors: Yuanyuan Xu, Shan Long, Yunning Yang, Feifan Zhou, Ning Dong, Kesong Yan, Bo Wang, Yachao Zeng, Nan Du, Xiaosong Li and Wei R. Chen

    Citation: Theoretical Biology and Medical Modelling 2019 16:12

    Content type: Research

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  34. After proteolysis, the majority of released amino acids from dietary protein are transported to the liver for gluconeogenesis or to peripheral tissues where they are used for protein synthesis and eventually c...

    Authors: Jeddidiah W. D. Griffin and Patrick C. Bradshaw

    Citation: Theoretical Biology and Medical Modelling 2019 16:11

    Content type: Research

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  35. The mathematical design of optimal therapies to fight cancer is an important research field in today’s Biomathematics and Biomedicine given its relevance to formulate patient-specific treatments. Until now, ho...

    Authors: Pedro José Gutiérrez-Diez, Miguel Ángel López-Marcos, Julia Martínez-Rodríguez and Jose Russo

    Citation: Theoretical Biology and Medical Modelling 2019 16:10

    Content type: Research

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  36. There is an increasing need for complex computational models to perform in silico experiments as an adjunct to in vitro and in vivo experiments in immunology. We introduce Microscopic Stochastic Immune System ...

    Authors: Csaba Kerepesi, Tibor Bakács and Tamás Szabados

    Citation: Theoretical Biology and Medical Modelling 2019 16:9

    Content type: Software

    Published on:

  37. After publication of the original article

    Authors: Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen and Timmy Lee

    Citation: Theoretical Biology and Medical Modelling 2019 16:8

    Content type: Correction

    Published on:

    The original article was published in Theoretical Biology and Medical Modelling 2017 14:5

  38. The increasing amounts of genomics data have helped in the understanding of the molecular dynamics of complex systems such as plant and animal diseases. However, transcriptional regulation, although playing a ...

    Authors: Juan Camilo Castro, Ivan Valdés, Laura Natalia Gonzalez-García, Giovanna Danies, Silvia Cañas, Flavia Vischi Winck, Carlos Eduardo Ñústez, Silvia Restrepo and Diego Mauricio Riaño-Pachón

    Citation: Theoretical Biology and Medical Modelling 2019 16:7

    Content type: Research

    Published on:

  40. Mathematical models of diseases may provide a unified approach for establishing effective treatment strategies based on fundamental pathophysiology. However, models that are useful for clinical practice must o...

    Authors: Yukihiro Yamanaka, Kenko Uchida, Momoka Akashi, Yuta Watanabe, Arino Yaguchi, Shuji Shimamoto, Shingo Shimoda, Hitoshi Yamada, Masashi Yamashita and Hidenori Kimura

    Citation: Theoretical Biology and Medical Modelling 2019 16:5

    Content type: Research

    Published on:

  41. The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the feasibility of interrupting the parasite’s life cycle in endem...

    Authors: Norma Y. Sánchez-Torres, Juan R. Bobadilla, Juan P. Laclette and Marco V. José

    Citation: Theoretical Biology and Medical Modelling 2019 16:4

    Content type: Research

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  42. Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular ...

    Authors: Hamed Ghaffari, Jeffrey D. Varner and Linda R. Petzold

    Citation: Theoretical Biology and Medical Modelling 2019 16:3

    Content type: Research

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  43. Clostridium difficile (C. difficile) infection is an important cause of healthcare-associated diarrhea. Several factors such as admission of colonized patients, levels of serum antibodies in patients, and control...

    Authors: Farida Chamchod and Prasit Palittapongarnpim

    Citation: Theoretical Biology and Medical Modelling 2019 16:2

    Content type: Research

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  44. Mathematical modeling is now frequently used in outbreak investigations to understand underlying mechanisms of infectious disease dynamics, assess patterns in epidemiological data, and forecast the trajectory ...

    Authors: Kimberlyn Roosa and Gerardo Chowell

    Citation: Theoretical Biology and Medical Modelling 2019 16:1

    Content type: Research

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  45. The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. miRNAs regulate proteins expressions by arresting or degrading the mRNAs. The purpos...

    Authors: Edgar Manzanarez-Ozuna, Dora-Luz Flores, Everardo Gutiérrez-López, David Cervantes and Patricia Juárez

    Citation: Theoretical Biology and Medical Modelling 2018 15:24

    Content type: Research

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  46. Personalized medicine for patients receiving radiation therapy remains an elusive goal due, in part, to the limits in our understanding of the underlying mechanisms governing tumor response to radiation. The p...

    Authors: Hualiang Zhong, Stephen Brown, Suneetha Devpura, X. Allen Li and Indrin J. Chetty

    Citation: Theoretical Biology and Medical Modelling 2018 15:23

    Content type: Research

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  47. Many biological soft tissues are hydrated porous hyperelastic materials, which consist of a complex solid skeleton with fine voids and fluid filling these voids. Mechanical interactions between the solid and t...

    Authors: Satoko Hirabayashi and Masami Iwamoto

    Citation: Theoretical Biology and Medical Modelling 2018 15:21

    Content type: Research

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  49. Taenia solium is the aetiological agent of human taeniasis, pig cysticercosis and human neurocysticercosis, which are serious public health problems, especially in developing countries.

    Authors: Marco V. José, Juan R. Bobadilla, Norma Y. Sánchez-Torres and Juan Pedro Laclette

    Citation: Theoretical Biology and Medical Modelling 2018 15:18

    Content type: Research

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682

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