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  1. Content type: Research

    The mathematical design of optimal therapies to fight cancer is an important research field in today’s Biomathematics and Biomedicine given its relevance to formulate patient-specific treatments. Until now, ho...

    Authors: Pedro José Gutiérrez-Diez, Miguel Ángel López-Marcos, Julia Martínez-Rodríguez and Jose Russo

    Citation: Theoretical Biology and Medical Modelling 2019 16:10

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  2. Content type: Software

    There is an increasing need for complex computational models to perform in silico experiments as an adjunct to in vitro and in vivo experiments in immunology. We introduce Microscopic Stochastic Immune System ...

    Authors: Csaba Kerepesi, Tibor Bakács and Tamás Szabados

    Citation: Theoretical Biology and Medical Modelling 2019 16:9

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  3. Content type: Correction

    After publication of the original article

    Authors: Daniel Pike, Yan-Ting Shiu, Maheshika Somarathna, Lingling Guo, Tatyana Isayeva, John Totenhagen and Timmy Lee

    Citation: Theoretical Biology and Medical Modelling 2019 16:8

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    The original article was published in Theoretical Biology and Medical Modelling 2017 14:5

  4. Content type: Research

    The increasing amounts of genomics data have helped in the understanding of the molecular dynamics of complex systems such as plant and animal diseases. However, transcriptional regulation, although playing a ...

    Authors: Juan Camilo Castro, Ivan Valdés, Laura Natalia Gonzalez-García, Giovanna Danies, Silvia Cañas, Flavia Vischi Winck, Carlos Eduardo Ñústez, Silvia Restrepo and Diego Mauricio Riaño-Pachón

    Citation: Theoretical Biology and Medical Modelling 2019 16:7

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  6. Content type: Research

    Mathematical models of diseases may provide a unified approach for establishing effective treatment strategies based on fundamental pathophysiology. However, models that are useful for clinical practice must o...

    Authors: Yukihiro Yamanaka, Kenko Uchida, Momoka Akashi, Yuta Watanabe, Arino Yaguchi, Shuji Shimamoto, Shingo Shimoda, Hitoshi Yamada, Masashi Yamashita and Hidenori Kimura

    Citation: Theoretical Biology and Medical Modelling 2019 16:5

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  7. Content type: Research

    The application of effective vaccines against pig cysticercosis and mass chemotherapy against pig cysticercosis and human taeniasis have shown the feasibility of interrupting the parasite’s life cycle in endem...

    Authors: Norma Y. Sánchez-Torres, Juan R. Bobadilla, Juan P. Laclette and Marco V. José

    Citation: Theoretical Biology and Medical Modelling 2019 16:4

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  8. Content type: Research

    Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular ...

    Authors: Hamed Ghaffari, Jeffrey D. Varner and Linda R. Petzold

    Citation: Theoretical Biology and Medical Modelling 2019 16:3

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  9. Content type: Research

    Clostridium difficile (C. difficile) infection is an important cause of healthcare-associated diarrhea. Several factors such as admission of colonized patients, levels of serum antibodies in patients, and control...

    Authors: Farida Chamchod and Prasit Palittapongarnpim

    Citation: Theoretical Biology and Medical Modelling 2019 16:2

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  10. Content type: Research

    Mathematical modeling is now frequently used in outbreak investigations to understand underlying mechanisms of infectious disease dynamics, assess patterns in epidemiological data, and forecast the trajectory ...

    Authors: Kimberlyn Roosa and Gerardo Chowell

    Citation: Theoretical Biology and Medical Modelling 2019 16:1

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  11. Content type: Research

    The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. miRNAs regulate proteins expressions by arresting or degrading the mRNAs. The purpos...

    Authors: Edgar Manzanarez-Ozuna, Dora-Luz Flores, Everardo Gutiérrez-López, David Cervantes and Patricia Juárez

    Citation: Theoretical Biology and Medical Modelling 2018 15:24

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  12. Content type: Research

    Personalized medicine for patients receiving radiation therapy remains an elusive goal due, in part, to the limits in our understanding of the underlying mechanisms governing tumor response to radiation. The p...

    Authors: Hualiang Zhong, Stephen Brown, Suneetha Devpura, X. Allen Li and Indrin J. Chetty

    Citation: Theoretical Biology and Medical Modelling 2018 15:23

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  13. Content type: Research

    Many biological soft tissues are hydrated porous hyperelastic materials, which consist of a complex solid skeleton with fine voids and fluid filling these voids. Mechanical interactions between the solid and t...

    Authors: Satoko Hirabayashi and Masami Iwamoto

    Citation: Theoretical Biology and Medical Modelling 2018 15:21

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  15. Content type: Research

    Taenia solium is the aetiological agent of human taeniasis, pig cysticercosis and human neurocysticercosis, which are serious public health problems, especially in developing countries.

    Authors: Marco V. José, Juan R. Bobadilla, Norma Y. Sánchez-Torres and Juan Pedro Laclette

    Citation: Theoretical Biology and Medical Modelling 2018 15:18

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  19. Content type: Research

    Embryo transfer (ET) is a key step of assisted reproductive procedures, where the transferred medium containing the embryos is injected into the uterine cavity through a transcervical catheter and blended with...

    Authors: Dali Ding, Weiping Shi and Yang Shi

    Citation: Theoretical Biology and Medical Modelling 2018 15:20

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  21. Content type: Research

    The acidity of human body fluids, expressed by the pH, is physiologically regulated in a narrow range, which is required for the proper function of cellular metabolism. Acid-base disorders are common especiall...

    Authors: Filip Ježek and Jiří Kofránek

    Citation: Theoretical Biology and Medical Modelling 2018 15:14

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  22. Content type: Research

    Many vector-borne diseases co-circulate, as the viruses from the same family are also transmitted by the same vector species. For example, Zika and dengue viruses belong to the same Flavivirus family and are prim...

    Authors: Biao Tang, Xi Huo, Yanni Xiao, Shigui Ruan and Jianhong Wu

    Citation: Theoretical Biology and Medical Modelling 2018 15:13

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  23. Content type: Research

    Ketogenic therapy in the form of ketogenic diets or calorie restriction has been proposed as a metabolic treatment of high grade glioma (HGG) brain tumors based on mechanistic reasoning obtained mainly from an...

    Authors: Rainer J. Klement, Prasanta S. Bandyopadhyay, Colin E. Champ and Harald Walach

    Citation: Theoretical Biology and Medical Modelling 2018 15:12

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  24. Content type: Research

    Mathematical modeling has become a tool used to address many emerging diseases. One of the most basic and popular modeling frameworks is the compartmental model. Unfortunately, most of the available compartmen...

    Authors: Parinya Suparit, Anuwat Wiratsudakul and Charin Modchang

    Citation: Theoretical Biology and Medical Modelling 2018 15:11

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  25. Content type: Research

    Antiretroviral therapy (ART) has become the standard of care for patients with HIV infection in South Africa and has led to the reduction in AIDS related morbidity and mortality. In developing countries, the n...

    Authors: Claris Shoko and Delson Chikobvu

    Citation: Theoretical Biology and Medical Modelling 2018 15:10

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  26. Content type: Research

    Unlike the epidemic of yellow fever from 2016 to 17 in Brazil mostly restricted to the States of Minas Gerais and Espirito Santo, the epidemic from 2017 to 18 mainly involved São Paulo and Rio de Janeiro and r...

    Authors: Yohei Sakamoto, Takayuki Yamaguchi, Nao Yamamoto and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2018 15:9

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  27. Content type: Research

    The process by which blood cells are formed is referred to as hematopoiesis. This process involves a complex sequence of phases that blood cells must complete. During hematopoiesis, a small fraction of cells unde...

    Authors: Christina L. Mouser, Eliana S. Antoniou and Evros K. Vassiliou

    Citation: Theoretical Biology and Medical Modelling 2018 15:8

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  28. Content type: Research

    Environmentally growing pathogens present an increasing threat for human health, wildlife and food production. Treating the hosts with antibiotics or parasitic bacteriophages fail to eliminate diseases that gr...

    Authors: Ilona Merikanto, Jouni T. Laakso and Veijo Kaitala

    Citation: Theoretical Biology and Medical Modelling 2018 15:7

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  29. Content type: Research

    It is believed that sexually active people, i.e. people having multiple or concurrent sexual partners, are at a high risk of sexually transmitted infections (STI), but they are likely to be more aware of the r...

    Authors: Nao Yamamoto, Keisuke Ejima and Hiroshi Nishiura

    Citation: Theoretical Biology and Medical Modelling 2018 15:6

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  31. Content type: Research

    The effects of current anthropogenic influences on eelgrass (Zostera marina) meadows are noticeable. Eelgrass ecological services grant important benefits for mankind. Preservation of eelgrass meadows include sev...

    Authors: Héctor Echavarría-Heras, Cecilia Leal-Ramírez, Enrique Villa-Diharce and Nohe Cazarez-Castro

    Citation: Theoretical Biology and Medical Modelling 2018 15:4

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  33. Content type: Research

    As HIV enters the human body, its main target is the CD4 cell which it turns into a factory that produces millions of other HIV particles. These HIV particles target new CD4 cells resulting in the progression ...

    Authors: Claris Shoko and Delson Chikobvu

    Citation: Theoretical Biology and Medical Modelling 2018 15:3

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  35. Content type: Research

    The small intestinal epithelium is a dynamic system with specialized cell types. The various cell populations of this tissue are continually renewed and replenished from stem cells that reside in the small int...

    Authors: Erik R. Barthel

    Citation: Theoretical Biology and Medical Modelling 2017 14:25

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  36. Content type: Research

    Increased computational resources have made individual based models popular for modelling epidemics. They have the advantage of incorporating heterogeneous features, including realistic population structures (...

    Authors: Abhishek Bakuli, Frank Klawonn, André Karch and Rafael Mikolajczyk

    Citation: Theoretical Biology and Medical Modelling 2017 14:26

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  37. Content type: Research

    Histamine (HA), a small molecule that is synthesized from the amino acid histidine, plays an important role in the immune system where it is associated with allergies, inflammation, and T-cell regulation. In t...

    Authors: Janet Best, H. F. Nijhout, Srimal Samaranayake, Parastoo Hashemi and Michael Reed

    Citation: Theoretical Biology and Medical Modelling 2017 14:24

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  38. Content type: Research

    National or local laws, norms or regulations (sometimes and in some countries) require medical providers to report notifiable diseases to public health authorities. Reporting, however, is almost always incompl...

    Authors: Marcos Amaku, Marcelo Nascimento Burattini, Eleazar Chaib, Francisco Antonio Bezerra Coutinho, David Greenhalgh, Luis Fernandez Lopez and Eduardo Massad

    Citation: Theoretical Biology and Medical Modelling 2017 14:23

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  40. Content type: Research

    Matching the frequency of the driving force to that of the system’s natural frequency of vibration results in greater amplitude response. Thus we hypothesize that applying ultrasound at the chondrocyte’s reson...

    Authors: April D. Miller, Anuradha Subramanian and Hendrik J. Viljoen

    Citation: Theoretical Biology and Medical Modelling 2017 14:21

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  42. Content type: Research

    Following the formation of a primary carcinoma, neoplastic cells metastasize by undergoing the epithelial mesenchymal transition (EMT), which is triggered by cues from inflammatory and stromal cells in the mic...

    Authors: Kelsey Gasior, Marlene Hauck, Alyson Wilson and Sudin Bhattacharya

    Citation: Theoretical Biology and Medical Modelling 2017 14:19

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  43. Content type: Review

    The genetic diversity of cancer and the dynamic interactions between heterogeneous tumor cells, the stroma and immune cells present daunting challenges to the development of effective cancer therapies. Althoug...

    Authors: Youcef Derbal

    Citation: Theoretical Biology and Medical Modelling 2017 14:18

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  44. Content type: Research

    Despite high vaccination coverage, many childhood infections pose a growing threat to human populations. Accurate disease forecasting would be of tremendous value to public health. Forecasting disease emergenc...

    Authors: Paige B. Miller, Eamon B. O’Dea, Pejman Rohani and John M. Drake

    Citation: Theoretical Biology and Medical Modelling 2017 14:17

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  45. Content type: Review

    The public benefit of test-and-treat has induced a need to justify goodness for the public, and mathematical modeling studies have played a key role in designing and evaluating the test-and-treat strategy for ...

    Authors: Kyeongah Nah, Hiroshi Nishiura, Naho Tsuchiya, Xiaodan Sun, Yusuke Asai and Akifumi Imamura

    Citation: Theoretical Biology and Medical Modelling 2017 14:16

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  47. Content type: Research

    A large epidemic of cholera, caused by Vibrio cholerae, serotype Ogawa, has been ongoing in Yemen, 2017. To improve the situation awareness, the present study aimed to forecast the cholera epidemic, explicitly ad...

    Authors: Hiroshi Nishiura, Shinya Tsuzuki, Baoyin Yuan, Takayuki Yamaguchi and Yusuke Asai

    Citation: Theoretical Biology and Medical Modelling 2017 14:14

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  48. Content type: Research

    Herpes Simplex Virus Type 2 (HSV-2) is one of the most common sexually transmitted diseases. Although there is still no licensed vaccine for HSV-2, a theoretical investigation of the potential effects of a vac...

    Authors: Jinliang Wang, Xiaoqing Yu, Heidi L. Tessmer, Toshikazu Kuniya and Ryosuke Omori

    Citation: Theoretical Biology and Medical Modelling 2017 14:13

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  50. Content type: Research

    With up to 240 million people chronically infected with hepatitis B worldwide, including an estimated 2 million in the United States, widespread screening is needed to link the infected to care and decrease th...

    Authors: Martin A. Sehr, Kartik D. Joshi, John M. Fontanesi, Robert J. Wong, Robert R. Bitmead and Robert G. Gish

    Citation: Theoretical Biology and Medical Modelling 2017 14:11

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682