Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Articles

Page 6 of 13

  1. Lung cancer is the major cause of mortality worldwide. Major signalling pathways that could play significant role in lung cancer therapy include (1) Growth promoting pathways (Epidermal Growth Factor Receptor/...

    Authors: Syeda Naqsh e Zahra, Naureen Aslam Khattak and Asif Mir

    Citation: Theoretical Biology and Medical Modelling 2013 10:1

    Content type: Research

    Published on:

  2. The theory of speciation is dominated by adaptationist thinking, with less attention to mechanisms that do not affect species adaptation. Degeneracy – the imperfect specificity of interactions between diverse ...

    Authors: Nicholas Atamas, Michael S Atamas, Faina Atamas and Sergei P Atamas

    Citation: Theoretical Biology and Medical Modelling 2012 9:56

    Content type: Research

    Published on:

  3. Acetaminophen (N-acetyl-para-aminophenol) is the most widely used over-the-counter or prescription painkiller in the world. Acetaminophen is metabolized in the liver where a toxic byproduct is produced that ca...

    Authors: Rotem Ben-Shachar, Yifei Chen, Shishi Luo, Catherine Hartman, Michael Reed and H Frederik Nijhout

    Citation: Theoretical Biology and Medical Modelling 2012 9:55

    Content type: Research

    Published on:

  4. To analyze the p42.3 gene expression in gastric cancer (GC) cell, find the relationship between protein structure and function, establish the regulatory network of p42.3 protein molecule and then to obtain the...

    Authors: Jianhua Zhang, Chunlei Lu, Zhigang Shang, Rui Xing, Li Shi and Youyong Lv

    Citation: Theoretical Biology and Medical Modelling 2012 9:53

    Content type: Research

    Published on:

  5. This paper analyzes a new semiphysiological ionic model, used recently to study reexitations and reentry in cardiac tissue [I.R. Cantalapiedra et al, PRE 82 011907 (2010)]. The aim of the model is to reproduce ac...

    Authors: Angelina Peñaranda, Inma R Cantalapiedra, Jean Bragard and Blas Echebarria

    Citation: Theoretical Biology and Medical Modelling 2012 9:50

    Content type: Research

    Published on:

  6. A detailed theoretical model that combines the conventional viscoelastic continuum description of cell motion with a dynamic active stress is presented. The model describes the ameboid cells movement comprisin...

    Authors: Mehrnush Mehrayin, Farhad Farmanzad, Masoud Mozafari, Daryoosh Vashaee and Lobat Tayebi

    Citation: Theoretical Biology and Medical Modelling 2012 9:49

    Content type: Research

    Published on:

  7. The objective of this study is to develop a comprehensive model of the electromechanical behavior of the rat ventricular myocyte to investigate the various factors influencing its contractile response.

    Authors: Abhilash Krishna, Miguel Valderrábano, Philip T Palade and John W Clark Jr

    Citation: Theoretical Biology and Medical Modelling 2012 9:48

    Content type: Research

    Published on:

  8. Rheumatoid arthritis (RA), a chronic autoimmune disease, affects sufferers in many different ways. Treatment of this chronic condition is particularly challenging. Traditional Chinese Medicine (TCM) provides a...

    Authors: Ya-jing Guo, Jiang Chen, Xin-gui Xiong, Dan Wu, Hao Zhu and Qing-hua Liang

    Citation: Theoretical Biology and Medical Modelling 2012 9:47

    Content type: Research

    Published on:

  9. Diabetes mellitus is a group of metabolic diseases with increased blood glucose concentration as the main symptom. This can be caused by a relative or a total lack of insulin which is produced by the β‐cells in t...

    Authors: Martina Gallenberger, Wolfgangzu Castell, Burkhard A Hense and Christina Kuttler

    Citation: Theoretical Biology and Medical Modelling 2012 9:46

    Content type: Research

    Published on:

  10. Most aerial plant parts are covered with a hydrophobic lipid-rich cuticle, which is the interface between the plant organs and the surrounding environment. Plant surfaces may have a high degree of hydrophobici...

    Authors: Mohamed Khayet and Victoria Fernández

    Citation: Theoretical Biology and Medical Modelling 2012 9:45

    Content type: Research

    Published on:

  11. The H1N1 influenza A virus has been circulating in the human population for over 95 years, first manifesting itself in the pandemic of 1917–1918. Initial mortality was extremely high, but dropped exponentially...

    Authors: Robert W Carter and John C Sanford

    Citation: Theoretical Biology and Medical Modelling 2012 9:42

    Content type: Research

    Published on:

  12. This paper presents a computational model that describes the growth of the bone as a function of the proliferation and hypertrophy of chondrocytes in the growth plate. We have included the effects of the mecha...

    Authors: Carlos A Narváez-Tovar and Diego A Garzón-Alvarado

    Citation: Theoretical Biology and Medical Modelling 2012 9:41

    Content type: Research

    Published on:

  13. The concept of conserved processes presents unique opportunities for using nonhuman animal models in biomedical research. However, the concept must be examined in the context that humans and nonhuman animals a...

    Authors: Ray Greek and Mark J Rice

    Citation: Theoretical Biology and Medical Modelling 2012 9:40

    Content type: Research

    Published on:

  14. Develop and validate particular, concrete, and abstract yet plausible in silico mechanistic explanations for large intra- and interindividual variability observed for eleven bioequivalence study participants. ...

    Authors: Sean HJ Kim, Andre J Jackson, Rim Hur and C Anthony Hunt

    Citation: Theoretical Biology and Medical Modelling 2012 9:39

    Content type: Research

    Published on:

  15. We investigated the relationship of End-to-end distance between VH and VL with different peptide linkers and the activity of single-chain antibodies by computer-aided simulation. First, we developed (G4S)n (where...

    Authors: Jianhua Zhang, Shanhong Liu, Zhigang Shang, Li Shi and Jun Yun

    Citation: Theoretical Biology and Medical Modelling 2012 9:38

    Content type: Research

    Published on:

  16. Authors: Piernicola Pedicini, Rocchina Caivano, Barbara A Jereczek-Fossa, Lidia Strigari, Barbara Vischioni, Daniela Alterio, Marta Cremonesi, Francesca Botta, Antonio Nappi, Giuseppina Improta, Giovanni Storto, Alba Fiorentino, Marcello Benassi, Roberto Orecchia and Vincenzo Fusco

    Citation: Theoretical Biology and Medical Modelling 2012 9:37

    Content type: Erratum

    Published on:

    The original article was published in Theoretical Biology and Medical Modelling 2012 9:23

  17. The invasion-metastasis cascade of cancer involves a process of parallel progression. A biological interface (module) in which cells is linked with ECM (extracellular matrix) by CAMs (cell adhesion molecules) ...

    Authors: Feng-Chou Tsai, Mei-Chuan Wang, Jeng-Fan Lo, Chih-Ming Chou and Yi-Lu Lin

    Citation: Theoretical Biology and Medical Modelling 2012 9:36

    Content type: Research

    Published on:

  18. Discovering new biomarkers has a great role in improving early diagnosis of Hepatocellular carcinoma (HCC). The experimental determination of biomarkers needs a lot of time and money. This motivates this work ...

    Authors: Nagwan M Abdel Samee, Nahed H Solouma and Yasser M Kadah

    Citation: Theoretical Biology and Medical Modelling 2012 9:34

    Content type: Research

    Published on:

  19. Proteolytic degradation of the extracellular matrix (ECM) is a key event in tumour metastasis and invasion. Matrix metalloproteinases (MMPs) are a family of endopeptidases that degrade most of the components o...

    Authors: Takashi Saitou, Keiko Itano, Daisuke Hoshino, Naohiko Koshikawa, Motoharu Seiki, Kazuhisa Ichikawa and Takashi Suzuki

    Citation: Theoretical Biology and Medical Modelling 2012 9:33

    Content type: Research

    Published on:

  20. The human granulocyte colony-stimulating factor (G-CSF) is routinely applied to support recovery of granulopoiesis during the course of cytotoxic chemotherapies. However, optimal use of the drug is largely unk...

    Authors: Markus Scholz, Sibylle Schirm, Marcus Wetzler, Christoph Engel and Markus Loeffler

    Citation: Theoretical Biology and Medical Modelling 2012 9:32

    Content type: Research

    Published on:

  21. The role of the immune system in tumor progression has been a subject for discussion for many decades. Numerous studies suggest that a low immune response might be beneficial, if not necessary, for tumor growt...

    Authors: Heiko Enderling, Lynn Hlatky and Philip Hahnfeldt

    Citation: Theoretical Biology and Medical Modelling 2012 9:31

    Content type: Research

    Published on:

  22. Human papillomavirus (HPV) types 16 and 18 are the high-risk, sexually transmitted infectious causes of most cervical intraepithelial neoplasias (CIN) or cancers. While efficacious vaccines to reduce the sexua...

    Authors: Misaki Wayengera

    Citation: Theoretical Biology and Medical Modelling 2012 9:30

    Content type: Research

    Published on:

  23. This study investigated two different mathematical models for the kinetics of anaerobic power. Model 1 assumes that the work power is linear with the work rate, while Model 2 assumes a linear relationship betw...

    Authors: John F Moxnes, Kjell Hausken and Øyvind Sandbakk

    Citation: Theoretical Biology and Medical Modelling 2012 9:29

    Content type: Research

    Published on:

  24. While many branches of natural science have embraced group theory reaping enormous advantages for their respective fields, clinical medicine lacks to date such applications. Here we intend to explain a prototy...

    Authors: Jitsuki Sawamura, Shigeru Morishita and Jun Ishigooka

    Citation: Theoretical Biology and Medical Modelling 2012 9:28

    Content type: Research

    Published on:

  25. Super-macromolecular complexes play many important roles in eukaryotic cells. Classical structural biological studies focus on their complicated molecular structures, physical interactions and biochemical modi...

    Authors: Yue Zhao and Qimin Zhan

    Citation: Theoretical Biology and Medical Modelling 2012 9:26

    Content type: Review

    Published on:

  26. To estimate the effects of heterogeneity on tumour cell sensitivity to radiotherapy combined with radiosensitizing agents attributable to differences in expression levels of Epidermal Growth Factor Receptor (EGFr

    Authors: Piernicola Pedicini, Rocchina Caivano, Barbara Alicia Jereczek-Fossa, Lidia Strigari, Barbara Vischioni, Daniela Alterio, Marta Cremonesi, Francesca Botta, Antonio Nappi, Giuseppina Improta, Giovanni Storto, Marcello Benassi and Roberto Orecchia

    Citation: Theoretical Biology and Medical Modelling 2012 9:23

    Content type: Research

    Published on:

    The Erratum to this article has been published in Theoretical Biology and Medical Modelling 2012 9:37

  27. Medical records accumulate data concerning patient health and the natural history of disease progression. However, methods to mine information systematically in a form other than an electronic health record ar...

    Authors: Eric Aslakson, Smadar Szekely, Suzanne D Vernon, Lucinda Bateman, Jan Baumbach and Yaki Setty

    Citation: Theoretical Biology and Medical Modelling 2012 9:22

    Content type: Research

    Published on:

  28. Human milk samples contain microvesicles similar to the retroviruses. These microvesicles contain mRNA transcripts and possess reverse transcriptase activity. They contain about 14,000 transcripts representing...

    Authors: M Kemal Irmak, Yesim Oztas and Emin Oztas

    Citation: Theoretical Biology and Medical Modelling 2012 9:20

    Content type: Review

    Published on:

  29. Computational identification of transcription factor binding sites (TFBSs) is a rapid, cost-efficient way to locate unknown regulatory elements. With increased potential for high-throughput genome sequencing, ...

    Authors: Mingfeng Tan, Dong Yu, Yuan Jin, Lei Dou, Beiping LI, Yuelan Wang, Junjie Yue and Long Liang

    Citation: Theoretical Biology and Medical Modelling 2012 9:19

    Content type: Research

    Published on:

  30. Transplantation is often the only way to treat a number of diseases leading to organ failure. To overcome rejection towards the transplanted organ (graft), immunosuppression therapies are used, which have cons...

    Authors: AndreaDe Gaetano, Alice Matone, Annamaria Agnes, Pasquale Palumbo, Francesco Ria and Sabina Magalini

    Citation: Theoretical Biology and Medical Modelling 2012 9:18

    Content type: Research

    Published on:

  31. Several formulations have been proposed in order to model human growth from birth to maturity. They are usually based on “ad hoc” heuristic assumptions. In the present contribution we adopt, as an alternative,...

    Authors: Antonio S Gliozzi, Caterina Guiot, Pier Paolo Delsanto and Dan A Iordache

    Citation: Theoretical Biology and Medical Modelling 2012 9:17

    Content type: Research

    Published on:

  32. Consensus exists that several bariatric surgery procedures produce a rapid improvement of glucose homeostasis in obese diabetic patients, improvement apparently uncorrelated with the degree of eventual weight ...

    Authors: Puntip Toghaw, Alice Matone, Yongwimon Lenbury and Andrea De GAETANO

    Citation: Theoretical Biology and Medical Modelling 2012 9:16

    Content type: Research

    Published on:

  33. An allometric relationship between different electrocardiogram (ECG) parameters and infarcted ventricular mass was assessed in a myocardial infarction (MI) model in New Zealand rabbits.

    Authors: Maria P Bonomini, Pedro D Arini, Germán E Gonzalez, Bruno Buchholz and Max E Valentinuzzi

    Citation: Theoretical Biology and Medical Modelling 2012 9:15

    Content type: Research

    Published on:

  34. This article proposes a model of bone remodeling that encompasses mechanical and electrical stimuli. The remodeling formulation proposed by Weinans and collaborators was used as the basis of this research, wit...

    Authors: Diego A Garzón-Alvarado, Angélica M Ramírez-Martínez and Carmen Alicia Cardozo de Martínez

    Citation: Theoretical Biology and Medical Modelling 2012 9:14

    Content type: Research

    Published on:

  35. Lordosis is the bending of the lumbar spine that gives the vertebral column of humans its characteristic ventrally convex curvature. Infants develop lordosis around the time when they acquire bipedal locomotio...

    Authors: Heiko Wagner, Anne Liebetrau, David Schinowski, Thomas Wulf and Marc HE de Lussanet

    Citation: Theoretical Biology and Medical Modelling 2012 9:13

    Content type: Research

    Published on:

  36. An accepted hypothesis states that coronary atherosclerosis (CA) is initiated by endothelial dysfunction due to inflammation and high levels of LDL-C, followed by deposition of lipids and macrophages from the ...

    Authors: Vladimir M Subbotin

    Citation: Theoretical Biology and Medical Modelling 2012 9:11

    Content type: Research

    Published on:

  37. Recent studies have implicated viral characteristics in accounting for the variation in the HIV set-point viral load (spVL) observed among individuals. These studies have suggested that the spVL might be a her...

    Authors: Diego F Cuadros and Gisela García-Ramos

    Citation: Theoretical Biology and Medical Modelling 2012 9:9

    Content type: Research

    Published on:

Annual Journal Metrics

Advertisement