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  1. Content type: Research

    Messenger RNA (mRNA) comprises three major parts: a 5'-UTR (UnTranslated Region), a coding region, and a 3'-UTR. The 3'-UTR contains signal sequences involved in polyadenylation, degradation and localization/s...

    Authors: Gonzalo E Aranda-Abreu, Ma Elena Hernández, Abraham Soto and Jorge Manzo

    Citation: Theoretical Biology and Medical Modelling 2005 2:33

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  2. Content type: Research

    The number of founding germ cells (FGCs) in mammals is of fundamental significance to the fidelity of gene transmission between generations, but estimates from various methods vary widely. In this paper we obt...

    Authors: Chang-Jiang Zheng, E Georg Luebeck, Breck Byers and Suresh H Moolgavkar

    Citation: Theoretical Biology and Medical Modelling 2005 2:32

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  3. Content type: Commentary

    The conception of anatomical entities as a hierarchy of infinitely graduated forms and the increase in the number of observed anatomical sub-entities and structural variables has generated a growing complexity, t...

    Authors: Fabio Grizzi and Maurizio Chiriva-Internati

    Citation: Theoretical Biology and Medical Modelling 2005 2:26

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  4. Content type: Research

    Embryonic stem cells (ESC) are pluripotent cells obtained from the inner cell mass (ICM) of blastocysts derived from in vitro culture associated with reproductive endocrinology therapy. Human ESCs are regarded as...

    Authors: Eric Scott Sills, Takumi Takeuchi, Noriko Tanaka, Queenie V Neri and Gianpiero D Palermo

    Citation: Theoretical Biology and Medical Modelling 2005 2:25

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  5. Content type: Review

    The authors' experience with experimentally produced femoral capital osteonecrosis in rats is reviewed: incising the periosteum at the base of the neck of the femur and cutting the ligamentum teres leads to co...

    Authors: Jacob Bejar, Eli Peled and Jochanan H Boss

    Citation: Theoretical Biology and Medical Modelling 2005 2:24

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  6. Content type: Research

    The study of the network between transcription factors and their targets is important for understanding the complex regulatory mechanisms in a cell. Unfortunately, with standard microarray experiments it is no...

    Authors: Anne-Laure Boulesteix and Korbinian Strimmer

    Citation: Theoretical Biology and Medical Modelling 2005 2:23

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  7. Content type: Research

    The need to execute a sequence of events in an orderly and timely manner is central to many biological processes, including cell cycle progression and cell differentiation. For self-perpetuating systems, such ...

    Authors: Noa Rappaport, Shay Winter and Naama Barkai

    Citation: Theoretical Biology and Medical Modelling 2005 2:22

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  8. Content type: Editorial

    Biology has a conceptual basis that allows one to build models and theorize across many life sciences, including medicine and medically-related disciplines. A dearth of good venues for publication has been per...

    Authors: Denys N Wheatley

    Citation: Theoretical Biology and Medical Modelling 2005 2:21

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  9. Content type: Research

    Transcription is the first step in cellular information processing. It is regulated by cis-acting elements such as promoters and operators in the DNA, and trans-acting elements such as transcription factors and s...

    Authors: Karthikeyan Sivaraman, Aswin Sai Narain Seshasayee, Krishnakumar Swaminathan, Geetha Muthukumaran and Gautam Pennathur

    Citation: Theoretical Biology and Medical Modelling 2005 2:20

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  10. Content type: Research

    Signaling pathways include intricate networks of reversible covalent modification cycles. Such multicyclic enzyme cascades amplify the input stimulus, cause integration of multiple signals and exhibit sensitiv...

    Authors: Vivek K Mutalik and KV Venkatesh

    Citation: Theoretical Biology and Medical Modelling 2005 2:19

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  11. Content type: Research

    Cell simulation, which aims to predict the complex and dynamic behavior of living cells, is becoming a valuable tool. In silico models of human red blood cell (RBC) metabolism have been developed by several la...

    Authors: Yoichi Nakayama, Ayako Kinoshita and Masaru Tomita

    Citation: Theoretical Biology and Medical Modelling 2005 2:18

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  12. Content type: Research

    Accommodation and breakdown of accommodation are important elements of information processing in nerve fibers, as they determine how nerve fibers react to natural slowly changing stimuli or electrical stimulat...

    Authors: Kristian Hennings, Lars Arendt-Nielsen and Ole K Andersen

    Citation: Theoretical Biology and Medical Modelling 2005 2:16

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  13. Content type: Research

    Mathematical models describing growth kinetics are very important for predicting many biological phenomena such as tumor volume, speed of disease progression, and determination of an optimal radiation and/or c...

    Authors: Mohammad Tabatabai, David Keith Williams and Zoran Bursac

    Citation: Theoretical Biology and Medical Modelling 2005 2:14

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  14. Content type: Research

    Blood viscosity is fundamentally important in clinical practice yet the apparent viscosity at very low shear rates is not well understood. Various conditions such as blunt trauma may lead to the appearance of ...

    Authors: Rovshan M Ismailov

    Citation: Theoretical Biology and Medical Modelling 2005 2:13

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  15. Content type: Research

    Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We so...

    Authors: DF Harney, RK Butler and RJ Edwards

    Citation: Theoretical Biology and Medical Modelling 2005 2:12

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  16. Content type: Research

    The present paper describes a topological model of biofeedback. This model incorporates input from a sensory organ and a transduction phase mediated through catecholamine production in the feedback path. The t...

    Authors: Tapas K Basak, Suman Halder, Madona Kumar, Renu Sharma and Bijoylaxmi Midya

    Citation: Theoretical Biology and Medical Modelling 2005 2:11

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  17. Content type: Research

    The exact relationship between hormonal activity and prostate cancer(PCa) has not yet been clearly defined. One of the key hormones associated with PCa is testosterone(T). However, both in vitro and in vivo studi...

    Authors: A Edward Friedman

    Citation: Theoretical Biology and Medical Modelling 2005 2:10

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  18. Content type: Research

    Bone adapts to mechanical strain by rearranging the trabecular geometry and bone density. The common finite element methods used to simulate this adaptation have inconsistencies regarding material properties a...

    Authors: Zhengyuan Wang and Adrian Mondry

    Citation: Theoretical Biology and Medical Modelling 2005 2:6

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  19. Content type: Research

    Propagation of repolarization is a phenomenon that occurs in cardiac muscle. We wanted to test whether this phenomenon would also occur in our model of simulated action potentials (APs) of cardiac muscle (CM) ...

    Authors: Nicholas Sperelakis, Lakshminarayanan Ramasamy and Bijoy Kalloor

    Citation: Theoretical Biology and Medical Modelling 2005 2:5

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  20. Content type: Research

    Analysis of growth and division often involves measurements made on cell populations, which tend to average data. The value of single cell analysis needs to be appreciated, and models based on findings from si...

    Authors: JM Mitchison

    Citation: Theoretical Biology and Medical Modelling 2005 2:4

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  21. Content type: Research

    There is a substantial discrepancy between in vitro and in vivo experiments. The purpose of the present work was development of a theoretical framework to enable improved prediction of in vivo response from in vi...

    Authors: Ross Barnard and Konstantin G Gurevich

    Citation: Theoretical Biology and Medical Modelling 2005 2:3

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  22. Content type: Research

    Binding of a bacteria to a eukaryotic cell triggers a complex network of interactions in and between both cells. P. aeruginosa is a pathogen that causes acute and chronic lung infections by interacting with the p...

    Authors: Ekaterina Shelest and Edgar Wingender

    Citation: Theoretical Biology and Medical Modelling 2005 2:2

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  23. Content type: Research

    Ki-1 (CD30) antigen expression is not found on peripheral blood cells but its expression can be induced in vitro on T and B lymphocytes by viruses and lectins. Expression of CD30 in normal tissues is very limi...

    Authors: Demetrio Tamiolakis, John Venizelos, Maria Lambropoulou, Silva Nikolaidou, Sophia Bolioti, Maria Tsiapali, Dionysios Verettas, Panagiotis Tsikouras, Athanasios Chatzimichail and Nikolas Papadopoulos

    Citation: Theoretical Biology and Medical Modelling 2005 2:1

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  24. Content type: Review

    The relationship between body mass (M) and standard metabolic rate (B) among living organisms remains controversial, though it is widely accepted that in many cases B is approximately proportional to the three...

    Authors: Paul S Agutter and Denys N Wheatley

    Citation: Theoretical Biology and Medical Modelling 2004 1:13

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  25. Content type: Commentary

    In a recent publication it was claimed that cultured mammalian cells, in contrast to yeasts, maintain a constant size distribution in the population without a size checkpoint. This inference may be challengeable.

    Authors: Akos Sveiczer, Bela Novak and J Murdoch Mitchison

    Citation: Theoretical Biology and Medical Modelling 2004 1:12

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  26. Content type: Research

    The Bunyaviridae family of enveloped RNA viruses includes five genuses, orthobunyaviruses, hantaviruses, phleboviruses, nairoviruses and tospoviruses. It has not been determined which Bunyavirus protein mediat...

    Authors: Courtney E Garry and Robert F Garry

    Citation: Theoretical Biology and Medical Modelling 2004 1:10

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  27. Content type: Research

    In a previous study, a model was developed to investigate the release of luteinizing hormone (LH) from pituitary cells in response to a short pulse of gonadotropin-releasing hormone (GnRH). The model included:...

    Authors: Talitha M Washington, J Joseph Blum, Michael C Reed and P Michael Conn

    Citation: Theoretical Biology and Medical Modelling 2004 1:9

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  28. Content type: Research

    Dense time series of metabolite concentrations or of the expression patterns of proteins may be available in the near future as a result of the rapid development of novel, high-throughput experimental techniqu...

    Authors: Siren R Veflingstad, Jonas Almeida and Eberhard O Voit

    Citation: Theoretical Biology and Medical Modelling 2004 1:8

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  29. Content type: Research

    Human Immunodeficiency Virus (HIV) infection is a dynamic interaction of the pathogen and the host uniquely defined by the preference of the pathogen for a major component of the immune defense of the host. Si...

    Authors: Slobodan Tepic

    Citation: Theoretical Biology and Medical Modelling 2004 1:7

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  30. Content type: Research

    The key to a rational treatment of elementary Mendelian genetics, specifically to an understanding of the origin of dominant and recessive traits, lies in the facts that: (1) alleles of genes encode polypeptid...

    Authors: John W Porteous

    Citation: Theoretical Biology and Medical Modelling 2004 1:6

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  31. Content type: Research

    Integral membrane proteins are the primary targets of novel drugs but are largely without solved structures. As a consequence, hydrophobic moment plot methodology is often used to identify putative transmembrane

    Authors: James Wallace, Onkabetse A Daman, Frederick Harris and David A Phoenix

    Citation: Theoretical Biology and Medical Modelling 2004 1:5

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  32. Content type: Research

    The present article corrects common textbook accounts of Mendel's experiments by re-establishing what he wrote and how he accounted for his observations. It notes the long-established tests for the validity of...

    Authors: John W Porteous

    Citation: Theoretical Biology and Medical Modelling 2004 1:4

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  33. Content type: Research

    The phenomenon of switch-like response to graded input signal is the theme involved in various signaling pathways in living systems. Positive feedback loops or double negative feedback loops embedded with nonl...

    Authors: Lopamudra Giri, Vivek K Mutalik and KV Venkatesh

    Citation: Theoretical Biology and Medical Modelling 2004 1:2

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