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  1. Content type: Reviewer acknowledgement

    The Editors of Theoretical Biology and Medical Modelling would like to thank all the Reviewers who have contributed to the journal in Volume 11 (2014).

    Authors: Hiroshi Nishiura, Edward Rietman and Rongling Wu

    Citation: Theoretical Biology and Medical Modelling 2015 12:4

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  2. Content type: Review

    One of the main challenges in cancer modelling is to improve the knowledge of tumor progression in areas related to tumor growth, tumor-induced angiogenesis and targeted therapies efficacy. For this purpose, i...

    Authors: Patricio Cumsille, Aníbal Coronel, Carlos Conca, Cristóbal Quiñinao and Carlos Escudero

    Citation: Theoretical Biology and Medical Modelling 2015 12:13

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  3. Content type: Research

    Chronic lymphocytic leukemia (CLL) is an incurable malignancy of mature B-lymphocytes, characterized as being a heterogeneous disease with variable clinical manifestation and survival. Mutational statuses of r...

    Authors: María Camila Álvarez-Silva, Sally Yepes, Maria Mercedes Torres and Andrés Fernando González Barrios

    Citation: Theoretical Biology and Medical Modelling 2015 12:12

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  4. Content type: Research

    The immunotherapy using dendritic cells (DCs) against different varieties of cancer is an approach that has been previously explored which induces a specific immune response. This work presents a mathematical ...

    Authors: E. Castillo-Montiel, J. C. Chimal-Eguía, J. Ignacio Tello, G. Piñon-Zaráte, M. Herrera-Enríquez and AE. Castell-Rodríguez

    Citation: Theoretical Biology and Medical Modelling 2015 12:11

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  5. Content type: Review

    The different phases of the eukaryotic cell cycle are exceptionally well-preserved phenomena. DNA decompaction, RNA and protein synthesis (in late G1 phase) followed by DNA replication (in S phase) and lipid synt...

    Authors: Jorgelindo da Veiga Moreira, Sabine Peres, Jean-Marc Steyaert, Erwan Bigan, Loïc Paulevé, Marcel Levy Nogueira and Laurent Schwartz

    Citation: Theoretical Biology and Medical Modelling 2015 12:10

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  6. Content type: Research

    Despite a vast literature, atherosclerosis and the associated ischemia/reperfusion injuries remain today in many ways a mystery. Why do atheromatous plaques make and store a supply of cholesterol and sulfate w...

    Authors: Stephanie Seneff, Robert M. Davidson, Ann Lauritzen, Anthony Samsel and Glyn Wainwright

    Citation: Theoretical Biology and Medical Modelling 2015 12:9

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  7. Content type: Research

    N-methyl-D-Aspartate (NMDA) and its receptors (NMDAR) play a critical role in glutamatergic neurotransmission. Ethanol molecules inhibit these receptors, and if the brain is exposed to ethanol ...

    Authors: Carlos A Gutierrez and Mary M Staehle

    Citation: Theoretical Biology and Medical Modelling 2015 12:8

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  8. Content type: Research

    It has been established that stochastic effects play an important role in spatio-temporal biochemical networks. A popular method of representing such stochastic systems is the Reaction Diffusion Master Equatio...

    Authors: Atiyo Ghosh, Andre Leier and Tatiana T Marquez-Lago

    Citation: Theoretical Biology and Medical Modelling 2015 12:5

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  9. Content type: Research

    In this paper, we modify our previously developed conjoint tumor-normal cell model in order to make a distinction between tumor cells that are responsive to chemotherapy and those that may show resistance.

    Authors: Mitra Shojania Feizabadi and Tarynn M Witten

    Citation: Theoretical Biology and Medical Modelling 2015 12:3

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  10. Content type: Research

    Chlamydia is the most common sexually transmitted bacterial infection in Scotland, and is associated with potentially serious reproductive outcomes, including pelvic inflammatory disease (PID) and tubal factor...

    Authors: Katharine J Looker, Lesley A Wallace and Katherine ME Turner

    Citation: Theoretical Biology and Medical Modelling 2015 12:2

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  11. Content type: Review

    A variety of topics are reviewed in the area of mathematical and computational modeling in biology, covering the range of scales from populations of organisms to electrons in atoms. The use of maximum entropy ...

    Authors: Jack A Tuszynski, Philip Winter, Diana White, Chih-Yuan Tseng, Kamlesh K Sahu, Francesco Gentile, Ivana Spasevska, Sara Ibrahim Omar, Niloofar Nayebi, Cassandra DM Churchill, Mariusz Klobukowski and Rabab M Abou El-Magd

    Citation: Theoretical Biology and Medical Modelling 2014 11:52

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  12. Content type: Research

    Papillomavirus binding factor (PBF) or zinc finger protein 395 is a transcription factor associated to a poor prognosis in patients with osteosarcoma, an aggressive bone cancer that predominantly affects adole...

    Authors: Paola Castillo, Abraham F Cetina, Alfonso Méndez-Tenorio, Lennane Michel Espinoza-Fonseca and Blanca L Barrón

    Citation: Theoretical Biology and Medical Modelling 2014 11:51

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  13. Content type: Research

    Lyme disease imposes increasing global public health challenges. To better understand the joint effects of seasonal temperature variation and host community composition on the pathogen transmission, a stage-st...

    Authors: Yijun Lou, Jianhong Wu and Xiaotian Wu

    Citation: Theoretical Biology and Medical Modelling 2014 11:50

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  14. Content type: Research

    Estimating the required dose in radiotherapy is of crucial importance since the administrated dose should be sufficient to eradicate the tumor and at the same time should inflict minimal damage on normal cells...

    Authors: Andrew Dhawan, Kamran Kaveh, Mohammad Kohandel and Sivabal Sivaloganathan

    Citation: Theoretical Biology and Medical Modelling 2014 11:49

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  15. Content type: Review

    Considering evolution of terrestrial animals as something happening only on flat continental plains seems wrong. Many mountains have arisen and disappeared over the geologic time scale, so in all periods some ...

    Authors: Sven Kurbel

    Citation: Theoretical Biology and Medical Modelling 2014 11:47

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  16. Content type: Research

    Cardiac arrhythmias are becoming one of the major health care problem in the world, causing numerous serious disease conditions including stroke and sudden cardiac death. Furthermore, cardiac arrhythmias are i...

    Authors: Nour Eddine Alaa, Hamid Lefraich and Imane El Malki

    Citation: Theoretical Biology and Medical Modelling 2014 11:46

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  17. Content type: Research

    Children receiving Total Body Irradiation (TBI) in preparation for Hematopoietic Stem Cell Transplantation (HSCT) are at risk for Growth Hormone Deficiency (GHD), which sometimes severely compromises their Fin...

    Authors: Chiara Galletto, Antonio Gliozzi, Daniele Nucera, Nicoletta Bertorello, Eleonora Biasin, Andrea Corrias, Patrizia Chiabotto, Franca Fagioli and Caterina Guiot

    Citation: Theoretical Biology and Medical Modelling 2014 11:44

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  18. Content type: Research

    Highly successful strategies to make populations more resilient to infectious diseases, such as childhood vaccinations programs, may nonetheless lead to unpredictable outcomes due to the interplay between seas...

    Authors: Mathew P Dafilis, Federico Frascoli, Jodie McVernon, Jane M Heffernan and James M McCaw

    Citation: Theoretical Biology and Medical Modelling 2014 11:43

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  19. Content type: Research

    One of the leading causes of death and illness within the agriculture industry is through unintentionally ingesting or inhaling organophosphate pesticides. OP intoxication directly inhibits acetylcholinesteras...

    Authors: Richard R Chapleau, Peter J Robinson, John J Schlager and Jeffery M Gearhart

    Citation: Theoretical Biology and Medical Modelling 2014 11:42

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  20. Content type: Review

    In the current era of antiviral drug therapy, combining multiple drugs is a primary approach for improving antiviral effects, reducing the doses of individual drugs, relieving the side effects of strong antivi...

    Authors: Yoshiki Koizumi and Shingo Iwami

    Citation: Theoretical Biology and Medical Modelling 2014 11:41

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  21. Content type: Research

    The various cell types and their relative numbers in multicellular organisms are controlled by growth factors and related extracellular molecules which affect genetic expression pathways. However, these substa...

    Authors: Cyril J Craven

    Citation: Theoretical Biology and Medical Modelling 2014 11:40

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  22. Content type: Research

    The optimal marker for cyclosporine (CsA) monitoring in transplantation patients remains controversial. However, there is a growing interest in the use of the area under the concentration-time curve (AUC), par...

    Authors: Sarem Sarem, Jun Li, Olivier Barriere, Catherine Litalien, Yves Théorêt, Anne-Laure Lapeyraque and Fahima Nekka

    Citation: Theoretical Biology and Medical Modelling 2014 11:39

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  23. Content type: Research

    This study uses dimensional analysis to derive the general second-order differential equation that underlies numerous physical and natural phenomena described by common mathematical functions. It eschews assum...

    Authors: Gordon R Kepner

    Citation: Theoretical Biology and Medical Modelling 2014 11:38

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  24. Content type: Research

    Prostate cancer is one of the most common malignant diseases and is characterized by heterogeneity in the clinical course. To date, there are no efficient morphologic features or genomic biomarkers that can ch...

    Authors: Rudong Li, Xiao Dong, Chengcheng Ma and Lei Liu

    Citation: Theoretical Biology and Medical Modelling 2014 11:37

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  25. Content type: Research

    Lung ischemia–reperfusion injury (LIRI) may occur in the region of the affected lung after reperfusion therapy. Inhaled NO may be useful in treating acute and chronic pulmonary thromboembolism (PTE) due to the...

    Authors: Chaosheng Deng, Minxia Yang, Qichang Lin, Yuanhua Yang, Zhenguo Zhai, Kaixiong Liu, Haibo Ding, Xiaoming Cao, Zhihua Huang, Lina Zhang and Jianming Zhao

    Citation: Theoretical Biology and Medical Modelling 2014 11:36

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  26. Content type: Research

    Despite rendering serum free thyroxine (FT4) and thyrotropin (TSH) within the normal population ranges broadly defined as euthyroidism, many patients being treated for hyperthyroidism and hypothyroidism persis...

    Authors: Melvin Khee-Shing Leow and Simon L Goede

    Citation: Theoretical Biology and Medical Modelling 2014 11:35

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  27. Content type: Research

    Early detection screening of asymptomatic populations for low prevalence cancers requires a highly specific test in order to limit the cost and anxiety produced by falsely positive identifications. Most solid ...

    Authors: Matthew A Firpo, Kenneth M Boucher and Sean J Mulvihill

    Citation: Theoretical Biology and Medical Modelling 2014 11:34

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  28. Content type: Research

    This work expands upon a previously developed exercise dynamic physiology model (DPM) with the addition of an anatomic pulmonary system in order to quantify the impact of lung damage on oxygen transport and ph...

    Authors: David A Shelley, Bryant L Sih and Laurel J Ng

    Citation: Theoretical Biology and Medical Modelling 2014 11:32

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  29. Content type: Research

    A number of cellular- and molecular-level studies of autophagy assessment have been carried out with the help of various biochemical and morphological indices. Still there exists ambiguity for the assessment o...

    Authors: Kyungreem Han, Jinwoong Kim and Moo Young Choi

    Citation: Theoretical Biology and Medical Modelling 2014 11:31

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  30. Content type: Research

    Immunoglobulin (IG) complementarity determining region (CDR) includes VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3. Of these, VH CDR3 plays a dominant role in recognizing and binding antigens. Three...

    Authors: Bin Shi, Long Ma, Xiaoyan He, Xiaomei Wang, Peng Wang, Li Zhou and Xinsheng Yao

    Citation: Theoretical Biology and Medical Modelling 2014 11:30

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  31. Content type: Research

    A previous theoretic model (Tumour Biol 2013;34:1–7.) that breast tumor types differ in the relative rate of tissue invasion was elaborated and developed on a consecutive case series.

    Authors: Sven Kurbel, Ksenija Marjanović and Branko Dmitrović

    Citation: Theoretical Biology and Medical Modelling 2014 11:29

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  32. Content type: Research

    In-silico models that attempt to capture and describe the physiological behavior of biological organisms, including humans, are intrinsically complex and time consuming to build and simulate in a computing env...

    Authors: Shaji Krishnan, Mark van Avesaat, Freddy J Troost, Henk FJ Hendriks and Albert A de Graaf

    Citation: Theoretical Biology and Medical Modelling 2014 11:28

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  33. Content type: Research

    The glycoprotein D (gD) is essential for Herpes B virus (BV) entry into mammalian cells. Nectin-1, an HSV-1 gD receptor, is found to be the receptor which mediated BV induced cell-cell fusion, while HVEM does ...

    Authors: Lingke Li, Zhengliang Qiu, Yan Li, Feng Liang, Huahu Ye, Yongqin Cai, Wanfeng Guo, Yan Li and Junjie Yue

    Citation: Theoretical Biology and Medical Modelling 2014 11:27

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  34. Content type: Research

    During plant and animal development, monolayer cell sheets display a stereotyped distribution of polygonal cell shapes. In interphase cells these shapes range from quadrilaterals to decagons, with a robust ave...

    Authors: William T Gibson, Boris Y Rubinstein, Emily J Meyer, James H Veldhuis, G Wayne Brodland, Radhika Nagpal and Matthew C Gibson

    Citation: Theoretical Biology and Medical Modelling 2014 11:26

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  35. Content type: Research

    The purpose of this study was the comparison of the calculated (MLSSC) and experimental power (MLSSE) in maximal lactate steady-state (MLSS) during cycling.

    Authors: Thomas Hauser, Jennifer Adam and Henry Schulz

    Citation: Theoretical Biology and Medical Modelling 2014 11:1

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    The Erratum to this article has been published in Theoretical Biology and Medical Modelling 2016 13:18

  36. Content type: Research

    Haematotoxicity of conventional chemotherapies often results in delays of treatment or reduction of chemotherapy dose. To ameliorate these side-effects, patients are routinely treated with blood transfusions o...

    Authors: Sibylle Schirm, Christoph Engel, Markus Loeffler and Markus Scholz

    Citation: Theoretical Biology and Medical Modelling 2014 11:24

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  37. Content type: Research

    Although the process of endocytosis of the low density lipoprotein (LDL) macromolecule and its receptor have been the subject of intense experimental research and modeling, there are still conflicting hypothes...

    Authors: Héctor Echavarria-Heras, Cecilia Leal-Ramirez and Oscar Castillo

    Citation: Theoretical Biology and Medical Modelling 2014 11:23

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  38. Content type: Research

    Mathematical modeling of virus dynamics has provided quantitative insights into viral infections such as influenza, the simian immunodeficiency virus/human immunodeficiency virus, hepatitis B, and hepatitis C....

    Authors: Hiroki Ikeda, Rob J de Boer, Kei Sato, Satoru Morita, Naoko Misawa, Yoshio Koyanagi, Kazuyuki Aihara and Shingo Iwami

    Citation: Theoretical Biology and Medical Modelling 2014 11:22

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  39. Content type: Research

    Inter-patient variations in tumour growth rate are usually interpreted as biological heterogeneity among patients due to, e.g., genetic variability. However, these variations might be a result of non-exponenti...

    Authors: Esmaeil Mehrara and Eva Forssell-Aronsson

    Citation: Theoretical Biology and Medical Modelling 2014 11:21

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  40. Content type: Research

    Arsenic is a major environmental toxin that is detoxified in the liver by biochemical mechanisms that are still under study. In the traditional metabolic pathway, arsenic undergoes two methylation reactions, e...

    Authors: Sean D Lawley, Jina Yun, Mary V Gamble, Megan N Hall, Michael C Reed and H Frederik Nijhout

    Citation: Theoretical Biology and Medical Modelling 2014 11:20

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  41. Content type: Research

    Computational modeling of Red Blood Cell (RBC) flow contributes to the fundamental understanding of microhemodynamics and microcirculation. In order to construct theoretical RBC models, experimental studies on...

    Authors: Swe Soe Ye, Yan Cheng Ng, Justin Tan, Hwa Liang Leo and Sangho Kim

    Citation: Theoretical Biology and Medical Modelling 2014 11:19

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  42. Content type: Research

    Superficial bladder cancer has been the subject of numerous studies for many years, but the evolution of the disease still remains not well understood. After the tumor has been surgically removed, it may reapp...

    Authors: Gregorio Rubio, Belén García-Mora, Cristina Santamaría and José Luis Pontones

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S3

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    This article is part of a Supplement: Volume 11 Supplement 1

  43. Content type: Research

    In this work, we propose the Halo test, a simple visual test based on a freeware software for quantifying and displaying night-vision disturbances perceived by subjects under different experimental conditions,...

    Authors: José J Castro, Carolina Ortiz, Antonio M Pozo, Rosario G Anera and Margarita Soler

    Citation: Theoretical Biology and Medical Modelling 2014 11(Suppl 1):S1

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    This article is part of a Supplement: Volume 11 Supplement 1

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